Figure 8
From: Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells
Summary of parthenolide-induced signaling pathway in NSCLC cell lines. Briefly, PTL induces ER stress response and eventually results in up-regulation of DDIT3 which could increase the expression of TNFRSF10B and PMAIP1 by binding to their promoter sites as a transcription factor. As the critical members of extrinsic and intrinsic apoptotic pathway respectively, TNFRSF10B and PMAIP1 consequently activate these two pathways to induce apoptosis in human lung cancer cells.