High expression of 5-hydroxymethylcytosine and isocitrate dehydrogenase 2 is associated with favorable prognosis after curative resection of hepatocellular carcinoma

Table 1 Summary of the correlations of 5-hmC and IDH2 protein expression with clinicopathological features in the training cohort (N = 318)

Clinicopathological indexes		No. of patients			No. of patients
Clinicopathological indexes		5-hmC ^Low	5-hmC ^High	P^†	IDH2 ^Low	IDH2 ^High	P^†
Sex	Female	18	36	0.007	28	26	0.765
	Male	141	123		131	133
Age(year)	≤50	55	65	0.247	60	60	1.000
	>50	104	94		99	99
HBsAg	Negative	30	26	0.556	28	28	1.000
	Positive	129	133		131	131
HCV	Negative	158	158	1.000	157	159	0.156
	Positive	1	1		2	0
AFP	≤20	83	37	<0.001	58	62	0.644
	>20	76	122		101	97
γ-GT(U/L)	≤54	87	81	0.500	78	90	0.178
	>54	72	78		81	69
Liver cirrhosis	No	32	26	0.384	23	35	0.081
	Yes	127	133		136	124
Tumor number	Single	131	134	0.652	134	131	0.652
	Multiple	28	25		25	28
Tumor size(cm)	≤5	97	108	0.197	99	106	0.412
	>5	62	51		60	53
Tumor encapsulation	Complete	94	88	0.496	93	89	0.650
	None	65	71		66	70
Microvascular invasion	Absent	113	107	0.466	106	114	0.331
	Present	46	52		53	45
Tumor differentiation	I + II	129	115	0.063	113	131	0.017
	III + IV	30	44		46	28
TNM stage	I	98	93	0.567	93	98	0.567
	II + III	61	66		66	61

Abbreviations: HBsAg, hepatitis B surface antigen; AFP, α-fetoprotein; γ-GT, γ-glutamyl transferase; TNM, tumor-node-metastasis.
^†A P-value < 0.05 was considered statistically significant. P-values were calculated using the Pearson chi-square test. Boldface type indicates significant values.

ISSN: 1756-9966