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Table 1 Summary of the correlations of 5-hmC and IDH2 protein expression with clinicopathological features in the training cohort (N = 318)

From: High expression of 5-hydroxymethylcytosine and isocitrate dehydrogenase 2 is associated with favorable prognosis after curative resection of hepatocellular carcinoma

Clinicopathological indexes   No. of patients No. of patients
  5-hmC Low 5-hmC High P IDH2 Low IDH2 High P
Sex Female 18 36 0.007 28 26 0.765
  Male 141 123   131 133  
Age(year) ≤50 55 65 0.247 60 60 1.000
  >50 104 94   99 99  
HBsAg Negative 30 26 0.556 28 28 1.000
  Positive 129 133   131 131  
HCV Negative 158 158 1.000 157 159 0.156
  Positive 1 1   2 0  
AFP ≤20 83 37 <0.001 58 62 0.644
  >20 76 122   101 97  
γ-GT(U/L) ≤54 87 81 0.500 78 90 0.178
  >54 72 78   81 69  
Liver cirrhosis No 32 26 0.384 23 35 0.081
  Yes 127 133   136 124  
Tumor number Single 131 134 0.652 134 131 0.652
  Multiple 28 25   25 28  
Tumor size(cm) ≤5 97 108 0.197 99 106 0.412
  >5 62 51   60 53  
Tumor encapsulation Complete 94 88 0.496 93 89 0.650
  None 65 71   66 70  
Microvascular invasion Absent 113 107 0.466 106 114 0.331
  Present 46 52   53 45  
Tumor differentiation I + II 129 115 0.063 113 131 0.017
  III + IV 30 44   46 28  
TNM stage I 98 93 0.567 93 98 0.567
  II + III 61 66   66 61  
  1. Abbreviations: HBsAg, hepatitis B surface antigen; AFP, α-fetoprotein; γ-GT, γ-glutamyl transferase; TNM, tumor-node-metastasis.
  2. A P-value < 0.05 was considered statistically significant. P-values were calculated using the Pearson chi-square test. Boldface type indicates significant values.