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Table 2 Summary of univariate and multivariate analyses of 5-hmC and IDH2 protein expression associated with survival and recurrence in the training cohort (N = 318)

From: High expression of 5-hydroxymethylcytosine and isocitrate dehydrogenase 2 is associated with favorable prognosis after curative resection of hepatocellular carcinoma

Factor OS TTR
Multivariate Multivariate
Univariate P Hazard ratio 95% CI P Univariate P Hazard ratio 95% CI P
Sex (female vs. male) 0.959    NA 0.083    NA
Age, years (≤50 vs. >50) 0.772    NA 0.597    NA
HBsAg (negative vs. positive) 0.983    NA 0.491    NA
AFP, ng/ml (≤20 vs. >20) 0.041 1.893 1.257–2.852 0.002 0.230    NA
γ-GT, U/L (≤54 vs. >54) 0.006 1.619 1.118–2.343 0.011 0.003 1.547 1.138–2.102 0.005
Liver cirrhosis (no vs. yes) 0.077    NA 0.009 1.824 1.135–2.930 0.013
Tumor number (single vs. multiple) 0.003    NS 0.002 1.651 1.135–2.402 0.009
Tumor size, cm (≤5 vs. >5) 0.009    NS 0.041    NS
Tumor encapsulation (complete vs. none) 0.261    NA 0.166    NA
Microvascular invasion (no vs. yes) 0.003    NS 0.001 1.775 1.287–2.448 <0.001
Tumor differentiation (I-II vs. III-IV) 0.138    NA 0.053    NA
TNM stage (I vs. II III) <0.001 2.048 1.412–2.971 <0.001 <0.001 1.649 1.134–2.397 0.009
5-hmC (low vs. high) <0.001 0.316 0.211–0.472 <0.001 0.001 0.462 0.335–0.636 <0.001
IDH2 (low vs. high) <0.001 0.405 0.275–0.594 <0.001 0.006 0.591 0.432–0.810 0.001
Combination of 5-hmC and IDH2 <0.001    <0.001 <0.001    <0.001
I versus II 0.002 3.987 1.890–8.413 <0.001 0.001 2.651 1.576–4.461 <0.001
I versus III 0.002 3.359 1.607–7.025 0.001 0.003 2.098 1.247–3.530 0.005
I versus IV <0.001 8.908 4.215–18.825 <0.001 <0.001 3.891 2.270–6.671 <0.001
  1. Abbreviations: OS, overall survival; TTR time to recurrence; AFP, α-fetoprotein; γ-GT, γ-glutamyl transferase; TNM, tumor-node-metastasis; CI, confidence interval; NA, not adopted; NS, not significant.
  2. Cox proportional hazards regression. Boldface type indicates significant values.
  3. I, 5-hmC High/IDH2 High; II, 5-hmC Low/IDH2 High; III, 5-hmC High/IDH2 Low; IV, 5-hmC Low/IDH2 Low.