Restoration of E-cadherin expression by selective Cox-2 inhibition and the clinical relevance of the epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma

Fujii, Ryoichi; Imanishi, Yorihisa; Shibata, Katsushi; Sakai, Nobuya; Sakamoto, Koji; Shigetomi, Seiji; Habu, Noboru; Otsuka, Kuninori; Sato, Yoichiro; Watanabe, Yoshihiro; Ozawa, Hiroyuki; Tomita, Toshiki; Kameyama, Kaori; Fujii, Masato; Ogawa, Kaoru

doi:10.1186/1756-9966-33-40

Journal of Experimental & Clinical Cancer Research

Table 2 Correlation between gene expression levels and clinicopathological factors

From: Restoration of E-cadherin expression by selective Cox-2 inhibition and the clinical relevance of the epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma

Variable		n		Cox-2	p value	SIP1	p value	Snail	p value	Twist	p value	CDH-1	p value
Age^a	< 60	25	median	3.964	0.583	3.191	0.773	1.071	0.273	12.469	0.119	13.681	0.878
			(range)	(0.640 - 61.171)		(0.035 - 17.376)		(0.020 - 6.229)		(0.000 - 64.312)		(0.100 - 45.381)
	≧ 60	15	median	4.443		2.926		0.936		6.947		13.881
			(range)	(0.427 - 52.766)		(0.059 - 9.482)		(0.099 - 2.361)		(0.936 - 20.548)		(0.841 - 24.494)
Gender^a	Male	35	median	4.037	0.817	3.200	0.247	0.986	0.611	9.794	0.746	12.670	0.379
			(range)	(0.427 - 61.171)		(0.035 - 17.376)		(0.020 - 6.229)		(0.000 - 64.312)		(0.100 - 45.381)
	Female	5	median	4.331		1.454		1.191		9.102		19.520
			(range)	(3.223 - 6.581)		(0.677 - 7.218)		(0.562 - 2.361)		(5.989 - 12.900)		(5.367 - 23.448)
T classification^b	1	2	coefficient	rs = -0.264	0.114	rs = 0.089	0.583	rs = -0.017	0.919	rs = 0.223	0.170	rs = -0.327	0.041*
	2	10
	3	22
	4	6
LN metastasis^a	N (-)	15	median	2.399	0.037*	2.926	0.964	0.983	0.800	6.947	0.226	18.801	0.020*
			(range)	(0.427 - 6.092)		(0.059 - 11.250)		(0.193 - 5.137)		(0.000 - 42.360)		(0.841 - 45.381)
	N (+)	25	median	4.443		3.602		1.094		12.037		10.688
			(range)	(1.379 - 61.171)		(0.035 - 17.376)		(0.020 - 6.229)		(0.936 - 64.312)		(0.100 - 23.697)
Histological grade^b	I	21	coefficient	rs = 0.155	0.338	rs = 0.462	0.004*	rs = 0.374	0.021*	rs = 0.381	0.019*	rs = -0.026	0.873
	II	12
	III	7
Vascular invasion^a	Negative	32	median	3.478	0.133	3.393	0.360	1.006	0.608	9.369	0.913	14.999	0.085
			(range)	(0.640 - 61.171)		(0.035 - 17.376)		(0.020 - 5.538)		(0.000 - 64.312)		(0.100 - 45.381)
	Positive	8	median	10.759		2.250		1.264		9.794		7.799
			(range)	(0.427 - 43.355)		(0.059 - 6.356)		(0.193 - 6.229)		(1.246 - 29.053)		(0.841 - 23.697)
Lymphatic invasion^a	Negative	22	median	4.037	0.800	3.939	0.195	0.936	0.554	9.027	0.554	15.966	0.192
			(range)	(0.640 - 61.171)		(0.035 - 11.250)		(0 020 - 5.137)		(0.000 - 64.312)		(1.373 - 38.234)
	Positive	18	median	4.733		2.155		1.104		10.915		10.694
			(range)	(0.427 - 60.921)		(0.059 - 17.376)		(0.086 - 6.229)		(0.936 - 31.933)		(0.100 - 45.381)
Perineural invasion^a	Negative	30	median	4.128	0.841	2.212	0.016*	1.006	0.286	7.720	0.008*	14.891	0.617
			(range)	(0.427 - 61.171)		(0.035 - 11.250)		(0.020 - 5.137)		(0.000 0 64.312)		(0.100 - 38.234)
	Positive	10	median	5.247		6.345		1.114		13.886		11.907
			(range)	(0.640 - 60.921)		(2.250 - 17.376)		(0.458 - 6.229)		(9.027 - 31.933)		(2.089 - 45.381)

^aMann-Whithey U test, ^bSpearman rank correlation coefficient.
*Statistically significant.
LN = lymph node, rs = correlation coefficient.

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ISSN: 1756-9966

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