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Figure 2 | Journal of Experimental & Clinical Cancer Research

Figure 2

From: Arsenic trioxide induces oxidative stress, DNA damage, and mitochondrial pathway of apoptosis in human leukemia (HL-60) cells

Figure 2

Arsenic trioxide modulates apoptotic proteins expression. (A) Western blots of intrinsic apoptotic pathway proteins in control and ATO-treated HL-60 cells. ATO exposure significantly increased the expression levels of Bax, cytochrome C, and decreased the expression level of Bcl-2 in a dose- dependent manner. (B) Densitometric analysis of ATO –induced apoptotic proteins expression in HL-60 cells. Data represent the means of three independent experiments ± SDs (*p < 0.01; **p < 0.05 and #p < 0.01).

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