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Figure 3 | Journal of Experimental & Clinical Cancer Research

Figure 3

From: Arsenic trioxide induces oxidative stress, DNA damage, and mitochondrial pathway of apoptosis in human leukemia (HL-60) cells

Figure 3

ATO changes mitochondrial membrane potential (Δψm). (A) ATO treatment was changed the mitochondrial membrane potential in a dose- dependent manner. [(B)(i-v)] There are three subsets of each treatment-DAPI (blue), JC-1 monomer (excitation 530 nm, green) and merged (blue/green). ATO treatment dose–dependently changed mitochondrial membrane potential and opened transition pores. It helped to release J-aggregate and continuously increased JC-1 monomer (green color) in a dose dependent manner in HL-60 cells.

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