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Figure 5 | Journal of Experimental & Clinical Cancer Research

Figure 5

From: Arsenic trioxide induces oxidative stress, DNA damage, and mitochondrial pathway of apoptosis in human leukemia (HL-60) cells

Figure 5

Arsenic trioxide induces release of cytochrome C protein from mitochondria and activation of caspase 3. [(A) (i-v)] Each set contains four subsets, a – cells stained with DAPI (blue); b- mitochondria stained with mitotracker red CMXRos (red, 250nM); c –cytochrome C protein tagged with fluorescent secondary antibody (green); and d – merged image of all previous three (a, b and c). Here, it is shown that cytochrome C was released from mitochondria in a dose- dependent manner. (B) Data also show a dose-dependent enhancement of caspase 3 activity with the ATO treatment of HL-60 cells.

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