Figure 3

AZD8931 inhibits proliferation and induces apoptosis in human IBC cells. SUM149 (A) and FC-IBC-02 (B) cells were treated with 0.01, 0.1, 1, or 2 μmol/L AZD8931 for 72 hrs. At the indicated times, MTS assay was performed by absorbance at 490 nm. Mean of 3 independent experiments with SD. *P < 0.001 compared to control. C and D. SUM149 and FC-IBC-02 cells were treated with 1 μmol/L AZD8931 for 48 or 72 hrs. Annexin V-positive cells were measured by Guava Nexin assay. Mean of 3 independent experiments with SD. P value compared to control.