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Table 2 IC:50s at 72 h of different UTR agonists and antagonists on bladder cancer cell lines

From: Urotensin II receptor determines prognosis of bladder cancer regulating cell motility/invasion

Cell lines

Compounds IC:50 (nM)

 

UII

Urantide

UPG83

UPG85

UPG84

T24

n.d.

350 ± 8

n.d.

n.d.

7 ± 0,6

RT112

n.d.

375 ± 6

n.d.

n.d.

n.d.

MCR

n.d.

n.d

n.d.

n.d.

9,8 ± 0,5

HT1376

n.d.

n.d.

1000 ± 9

n.d.

7,9 ± 0,4

  1. n.d.: not detectable; IC:50: drug concentration that induces the 50% of cell growth inhibition after 72 h from the beginning of the treatment; UII: urotensin II.