Quantification of EGFR mutations in primary and metastatic tumors in non-small cell lung cancer

Table 2 Quantitative measurement of EGFR mutation ratios in 3 primary tumor sites and one metastases of the same patient

ID	Mutation ratio (%) in different primary tumor sites					Mutation ratio (%) of metastases
ID	1	2	3	Median	Deviation (%)*	Mutation ratio (%) of metastases
E001	85.9	91.1	80.1	85.9	12.8	<10
E002	39.1	25.9	44	39.1	49.8	41
E003	<10	<10	<10	<10	0.0	<10
E004	82.2	76.7	66.9	76.7	20.3	13.3
E005	43.9	40.5	45.4	43.9	11.3	41.2
E006	35.4	42.7	39.3	39.3	18.7	<10
E007	70.1	71.8	66.5	70.1	7.6	72.9
E008	79.8	85.1	88.9	85.1	10.8	28.1
E009	66.1	64.3	49.3	64.3	28.0	45.9
E010	54.2	83.6	77.6	77.6	40.9	15.9
E011	<10	<10	<10	<10	0.0	<10
E012	<10	<10	<10	<10	0.0	<10
E013	44.7	27.2	49.1	44.7	54.3	22.9
E014	55.5	64.3	66.6	64.3	17.9	31.2
E015	18.7	23.6	13.9	18.7	51.8	Negative
E016	37.6	45.2	38.2	38.2	18.8	<10
E017	23.8	28.9	23.9	23.9	20.0	30.4
E018	62.3	69.6	58.2	62.3	18.0	43.8
E019	<10	<10	<10	<10	0.0	<10
E020	<10	<10	<10	<10	0.0	<10
E021	48.6	47	40.2	47	18.6	25.3
E022	28.6	35.1	34.9	34.9	19.8	20.9
E023	38.9	31.7	30.9	31.7	23.6	35.9
E024	<10	<10	<10	<10	0.0	<10
E025	44.9	38.4	45.1	44.9	15.7	<10
E026	78.9	75.2	79.2	78.9	5.1	54.9
E027	<10	<10	<10	<10	0.0	Negative
E028	67.3	54.7	55.3	55.3	21.3	52.1
E029	56.3	45.4	47.5	47.5	21.9	<10
E030	24.8	29.1	32.7	29.1	27.4	15.9
E031	59.7	48.1	55.3	55.3	21.3	42.8
E032	31.8	34.9	41.1	34.9	25.9	25.8
E033	<10	<10	<10	<10	0.0	<10
E034	33.8	30.1	27.7	30.1	20.0	28.9
E035	42.2	38.1	45.1	42.2	16.7	40.2
E036	<10	<10	<10	<10	0.0	Negative
E037	54.7	48.4	47.1	48.4	15.2	<10
E038	18.3	28.7	22.2	22.2	45.1	14.9
E039	40.2	41.8	30.2	40.2	31.0	28.9
E040	38.4	45.2	43.2	43.2	16.1	<10
E041	58.3	51.9	48.3	51.9	18.9	45.5
E042	45.3	40.2	42.6	42.6	11.9	45.9
E043	<10	<10	<10	<10	0.0	<10
E044	51.1	55.3	44.8	51.1	20.8	32.7
E045	65.7	62.9	71.2	65.7	12.5	49.8
E046	28.9	29.8	33.1	29.8	13.7	19.6
E047	43.8	45.9	49.7	45.9	12.7	43.1
E048	67.3	63.2	52.2	63.2	24.8	33.8
E049	39.1	43.9	30.8	39.1	34.5	27.8
E050	28.9	21.8	21.6	21.8	30.3	22.5

*Mutation deviation (%) of primary tumors was defined as (Emax-Emin)/Emd × 100%, where Emax, Emin, and Emd are the maximum, minimum and median value of EGFR mutation ratios at different primary tumor sites. If all three mutation ratios in primary sites were below 10%, the deviation was calculated as 0%.

ISSN: 1756-9966