Multiple functions of hypoxia-regulated miR-210 in cancer

Table 2 Targets of miR-210 functioning as tumor suppressor gene

Symbol	Description	Related function	Involved cell type
E2F3 [18, 21]	E2F transcription factor 3	Regulate apoptosis and cell proliferation	HeLa
			ACHN
			786-O
			Caki2
			HEK293
FGFRL1 [19, 26]	fibroblast growth factor receptor-like 1	Regulate cell proliferation	MCF10A
			KYSE-170
			KYSE-590
PTPN2 [30]	protein tyrosine phosphatase, non-receptor type 2	Regulate cell proliferation	ASC
PIK1 [29]	1-phosphatidylinositol 4-kinase	Regulate mitosis	CNE
PIK1 [29]	1-phosphatidylinositol 4-kinase	Regulate mitosis	HeLa
Cdc25B [29]	cell division cycle 25B	Regulate mitosis	CNE
Cdc25B [29]	cell division cycle 25B	Regulate mitosis	HeLa
Bub1B [29]	BUB1 mitotic checkpoint serine/threonine kinase B	Regulate mitosis	CNE
Bub1B [29]	BUB1 mitotic checkpoint serine/threonine kinase B	Regulate mitosis	HeLa
CCNF [29]	cyclin F	Regulate mitosis	CNE
CCNF [29]	cyclin F	Regulate mitosis	HeLa
Fam83D [29]	family with sequence similarity 83, member D	Regulate mitosis	CNE
Fam83D [29]	family with sequence similarity 83, member D	Regulate mitosis	HeLa
Bcl-2 [34]	B-cell CLL/lymphoma 2	Apoptosis	Neuro-2a

ISSN: 1756-9966