Figure 9
From: Characterization of the biological activity of a potent small molecule Hec1 inhibitor TAI-1
Differential expression of NDC80 (Hec1) and genes associated with NDC80 between subtypes of non-small cell lung cancer. (A) NDC80 (Hec1) (Affymetrix Probeset ID 204162_at) expression between adenocarcinoma and squamous cell carcinoma of lung in three different independent datasets (GSE8894, GSE3141 and GSE37745). The unit of Y axis is logarithm of expression intensity to the base 2. ANOVA was used to compare these two subtypes of NSCLC. (B) One way hierarchical clustering analysis of NDC80 gene and genes associated with NDC80 for subtypes of NSCLC in the same three independent datasets. The results consistently showed up-regulated expression of NDC80 and its closely associated genes (SPC25, NUF2 and Nek2) in squamous cell carcinoma of lung. Green: adenocarcinoma. Yellow: squamous cell carcinoma. The heat map scale is mean ± 2SD.