Table 2 Gene targets regulated by Snail1

E-cadherin

Epithelial marker, adherens junctions

Repression

[56],[57],[59] [61]

RKIP

Tumor suppressor

Repression

[68]

PTEN

Tumor suppressor

Repression

[70]

Occludin

Epithelial marker, tight junctions

Repression

[13],[75]

Claudins

Epithelial markers, tight junctions

Repression

[75]

Mucin-1

Epithelial marker

Repression

[83]

ZEB-1

Assists in induction of EMT

Upregulation

[83]

Vimentin

Mesenchymal marker

Upregulation

[54]

Fibronectin

Mesenchymal marker

Upregulation

[54]

Cytokeratin 18

Epithelial marker

Repression

[75],[83]

MMP-2/MMP-9

Mesenchymal markers

Upregulation

[113],[118]

LEF-1

Mesenchymal marker, assists in induction of EMT

Upregulation

[83],[125]