Table 4 Chemical inhibitors that target Snail1-induced EMT

GN25, GN29

Snail/p53 interaction

Reduced proliferation, tumor progression; increased tumor regression

Only effective in K-Ras activated cancer cells and on wild-type p53

[174],[175]

Co(III)-Ebox

Snail/E-cadherin interaction

Increased E-cadherin expression

[176]

Tranylcypromine

LSD1/LSD2

Decreased Snail’s effects on EMT markers

[177]

Trichostatin A

HDAC1/HDAC2

Reversed EMT marker expression

[177]

Pargyline

LSD1

Abrogated Snail-induced EMT

[177]

LBH589

HDAC

Abrogated Snail-induced EMT

[177]

Entinostat

HDAC

Increased E-cadherin and cytokeratin 18 expression, Decreased Twist, Snail, vimentin, N-cadherin; encouraged epithelial morphology; decreased cell migration

[178]