Table 4 Changes of prothrombotic markers in patients with prostate cancer who underwent surgery with balanced inhalation anaesthesia (BAL) before the induction of anaesthesia (T0), 1 hr post-surgery (T1) and 24 hrs post-surgery (T2)
| Â | T0 | T1 | T2 | P | ||
|---|---|---|---|---|---|---|
| Â | Â | Â | Â | T0 vs T1 | T1 vs T2 | T0 vs T2 |
Screening clotting time | Â | Â | Â | Â | Â | Â |
- PT (%) | 91.4 (1.4) | 86.8 (1.6) | 81.8 (1.4) | 0.007 | 0.02 | 0.001 |
- PTT (sec) | 30.1 (0.4) | 26.2 (0.7) | 28.3 (0.6) | 0.001 | 0.02 | 0.01 |
Procoagulant markers | Â | Â | Â | Â | Â | Â |
- Fibrinogen (mg/dL) | 318.5 (8.6) | 301.3 (10.9) | 372.4 (11.2) | 0.21 | 0.001 | 0.001 |
- TAT (ng/L) | 6.2 (0.8) | 19.2 (3.1) | 6.7 (0.8) | 0.002 | 0.002 | 0.42 |
- F1 + 2 (pmol/L) | 182.4 (11.8) | 558.1 (65.6) | 266.8 (19.2) | 0.001 | 0.001 | 0.001 |
- FVIII (%) | 123.4 (4.8) | 228.2 (15.8) | 169.2 (6.2) | 0.001 | 0.001 | 0.001 |
Fibrinolysis markers | Â | Â | Â | Â | Â | Â |
- PAI-1 (ng/ml) | 14.1 (1.4) | 21.7 (15.8) | 22.6 (2.4) | 0.16 | 0.86 | 0.002 |
- D-dimer (μg/L) | 175.5 (22.6) | 622.1 (175.4) | 421.3 (30.6) | 0.003 | 0.07 | 0.001 |
Haemostatic system inhibitors | Â | Â | Â | Â | Â | Â |
- AT (%) | 97.8 (1.7) | 92.0 (1.7) | 89.1 (1.8) | 0.04 | 0.25 | 0.001 |
- protein C (%) | 105.2 (3.8) | 99.3 (2.7) | 88.5 (2.7) | 0.18 | 0.03 | 0.001 |
- protein S (%) | 95.6 (2.4) | 91.2 (2.4) | 81.8 (2.6) | 0.08 | 0.01 | 0.001 |
Platelet-aggregating properties | Â | Â | Â | Â | Â | Â |
- p-selectin (ng/ml) | 41.5 (2.7) | 40.7 (2.9) | 40.2 (2.8) | 0.65 | 0.88 | 0.18 |