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Table 4 Changes of prothrombotic markers in patients with prostate cancer who underwent surgery with balanced inhalation anaesthesia (BAL) before the induction of anaesthesia (T0), 1 hr post-surgery (T1) and 24 hrs post-surgery (T2)

From: Perioperative changes in pro and anticoagulant factors in prostate cancer patients undergoing laparoscopic and robotic radical prostatectomy with different anaesthetic techniques

  T0 T1 T2 P
     T0 vs T1 T1 vs T2 T0 vs T2
Screening clotting time       
- PT (%) 91.4 (1.4) 86.8 (1.6) 81.8 (1.4) 0.007 0.02 0.001
- PTT (sec) 30.1 (0.4) 26.2 (0.7) 28.3 (0.6) 0.001 0.02 0.01
Procoagulant markers       
- Fibrinogen (mg/dL) 318.5 (8.6) 301.3 (10.9) 372.4 (11.2) 0.21 0.001 0.001
- TAT (ng/L) 6.2 (0.8) 19.2 (3.1) 6.7 (0.8) 0.002 0.002 0.42
- F1 + 2 (pmol/L) 182.4 (11.8) 558.1 (65.6) 266.8 (19.2) 0.001 0.001 0.001
- FVIII (%) 123.4 (4.8) 228.2 (15.8) 169.2 (6.2) 0.001 0.001 0.001
Fibrinolysis markers       
- PAI-1 (ng/ml) 14.1 (1.4) 21.7 (15.8) 22.6 (2.4) 0.16 0.86 0.002
- D-dimer (μg/L) 175.5 (22.6) 622.1 (175.4) 421.3 (30.6) 0.003 0.07 0.001
Haemostatic system inhibitors       
- AT (%) 97.8 (1.7) 92.0 (1.7) 89.1 (1.8) 0.04 0.25 0.001
- protein C (%) 105.2 (3.8) 99.3 (2.7) 88.5 (2.7) 0.18 0.03 0.001
- protein S (%) 95.6 (2.4) 91.2 (2.4) 81.8 (2.6) 0.08 0.01 0.001
Platelet-aggregating properties       
- p-selectin (ng/ml) 41.5 (2.7) 40.7 (2.9) 40.2 (2.8) 0.65 0.88 0.18
  1. Values are mean (SD).