Table 1 Aberrant expression of p68 in cancer

Colorectal cancer

elevated in HCT-116, LoVo, SW480 and SW620 cell lines relative to normal colon cell lines

β-catenin, p21

Singh C et al., 1995 [41]

Shin S et al., 2007 [46]

higher p68 positive rate of adenocarcinoma than matched normal tissue, and the expression degree increases from polyp to adenoma and adenocarcinoma in sequence

Causevic M et al., 2001 [47]

Breast cancer

increased progressively from the luminal to basal breast cancer cell lines(38 cell lines)

miR-182,ERα

Haines GK et al., 1996 [42]

elevated in cancer tissue than in normal breast tissue

Wang D et al., 2012 [48]

higher DDX5 positive rate in malignant biopsies than benign

Fujita T et al., 2003 [49]

Head and neck squamous cell carcinoma

elevated in (UMSCC)-10B and (UTSCC)-19A cell lines compared two benign epithelial keratinocytes

Not determined

Beier UH et al., 2006 [50]

Prostate cancer

higher p68 positive rate in PCa biopsies than in BPH

AR

Clark EL et al., 2008 [10]

Salivary gland pleomorphic adenomas

elevated in adenoma than matched normal salivary gland tissue

Not determined

Zhang X et al., 2009 [51]

Leukemia

higher level in SupT1, DND41, HBP-ALL, KOPT1, Jurkat, MOLT4, MOLT13, MOLT15 and REX cell lines than selected acute myeloid leukemia cell lines

NOTCH1, MAML1

Lin S et al., 2012 [45]

elevated in human T-ALL bone marrow samples compared with normal T cells

Glioma

elevated in H-4, HS-683, U-87, U-251, and U-343 cell lines

NF-kappaB, p50

Wang R et al., 2012 [52]

elevated in high-grade human glioma relative to low-grade glioma and normal adjacent brain tissue

Cutaneous squamous cell carcinoma

elevated in carcinoma than adjacent tissues and normal foreskin tissues

Not determined

Wang SJ et al., 2012 [44]

higher in carcinoma cases with metastasis than those without metastasis

Hepatocellular carcinoma

down-regulated in HBV-positive and NBNC HCC tissues compared with matched adjacent non-cancerous liver

Not determined

Kitagawa N et al., 2013 [53]