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Table 1 Aberrant expression of p68 in cancer

From: P68 RNA helicase as a molecular target for cancer therapy

Type of tumor Expression level of p68 Involved factor Author/reference
Colorectal cancer elevated in HCT-116, LoVo, SW480 and SW620 cell lines relative to normal colon cell lines β-catenin, p21 Singh C et al., 1995 [41]
Shin S et al., 2007 [46]
higher p68 positive rate of adenocarcinoma than matched normal tissue, and the expression degree increases from polyp to adenoma and adenocarcinoma in sequence Causevic M et al., 2001 [47]
Breast cancer increased progressively from the luminal to basal breast cancer cell lines(38 cell lines) miR-182,ERα Haines GK et al., 1996 [42]
elevated in cancer tissue than in normal breast tissue Wang D et al., 2012 [48]
higher DDX5 positive rate in malignant biopsies than benign Fujita T et al., 2003 [49]
Head and neck squamous cell carcinoma elevated in (UMSCC)-10B and (UTSCC)-19A cell lines compared two benign epithelial keratinocytes Not determined Beier UH et al., 2006 [50]
Prostate cancer higher p68 positive rate in PCa biopsies than in BPH AR Clark EL et al., 2008 [10]
Salivary gland pleomorphic adenomas elevated in adenoma than matched normal salivary gland tissue Not determined Zhang X et al., 2009 [51]
Leukemia higher level in SupT1, DND41, HBP-ALL, KOPT1, Jurkat, MOLT4, MOLT13, MOLT15 and REX cell lines than selected acute myeloid leukemia cell lines NOTCH1, MAML1 Lin S et al., 2012 [45]
elevated in human T-ALL bone marrow samples compared with normal T cells
Glioma elevated in H-4, HS-683, U-87, U-251, and U-343 cell lines NF-kappaB, p50 Wang R et al., 2012 [52]
elevated in high-grade human glioma relative to low-grade glioma and normal adjacent brain tissue
Cutaneous squamous cell carcinoma elevated in carcinoma than adjacent tissues and normal foreskin tissues Not determined Wang SJ et al., 2012 [44]
higher in carcinoma cases with metastasis than those without metastasis
Hepatocellular carcinoma down-regulated in HBV-positive and NBNC HCC tissues compared with matched adjacent non-cancerous liver Not determined Kitagawa N et al., 2013 [53]