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Table 3 Frequency of promoter hypermethylation in patients with recurrent or non recurrent disease

From: Promoter methylation of tumor suppressor genes in pre-neoplastic lesions; potential marker of disease recurrence

Gene ID % R % NR Overall series P
(Total = 31) (Total = 47) (Total = 78)
FHIT 38.71 (12/31) 2.13 (1/47) 16.67 (13/78) 3.1E-05
MLH1 25.81 (8/31) 2.13 (1/47) 11.54 (9/78) 0.002
ATM 22.58 (7/31) 2.13 (1/47) 10.26 (8/78) 0.006
TP73 35.48 (11/31) 12.77 (6/47) 21.79 (17/78) 0.025
BRCA1 9.68 (3/31) 0.00 (0/47) 3.85 (3/78) 0.059
CHFR 29.03 (9/31) 10.64 (5/47) 17.95 (14/78) 0.068
IGSF4 12.90 (4/31) 2.13 (1/47) 6.41 (5/78) 0.078
ESR1 70.97 (22/31) 85.11 (40/47) 79.49 (62/78) 0.158
DAPK1 22.58 (7/31) 10.64 (5/47) 15.38 (12/78) 0.203
CDKN2B 45.16 (14/31) 29.79 (14/47) 35.90 (28/78) 0.228
RASSF1 CpG1 41.94 (13/31) 29.79 (14/47) 34.62 (27/78) 0.333
RASSF1 CpG2 12.90 (4/31) 6.38 (3/47) 8.97 (7/78) 0.427
HIC1 16.13 (5/31) 8.51 (4/47) 11.54 (9/78) 0.471
CDKN2A 22.58 (7/31) 14.89 (7/47) 17.95 (14/78) 0.548
CASP8 6.45 (2/31) 2.13 (1/47) 3.85 (3/78) 0.560
CDH13 80.65 (25/31) 74.47 (35/47) 76.92 (60/78) 0.592
CD44 3.23 (1/31) 8.51 (4/47) 6.41 (5/78) 0.643
BRCA2 12.90 (4/31) 8.51 (4/47) 10.26 (8/78) 0.706
RARB 48.39 (15/31) 44.68 (21/47) 46.15 (36/78) 0.818
APC 45.16 (14/31) 48.94 (23/47) 47.44 (37/78) 0.819
TIMP3 38.71 (12/31) 36.17 (17/47) 37.18 (29/78) 1.000
CDKN1B 9.68 (3/31) 8.51 (4/47) 8.97 (7/78) 1.000
VHL 6.45 (2/31) 6.38 (3/47) 6.41 (5/78) 1.000
PTEN 3.23 (1/31) 4.26 (2/47) 3.85 (3/78) 1.000
  1. Abbreviations: R recurrent disease, NR non recurrent disease. P-value < 0.05.