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Table 3 Frequency of promoter hypermethylation in patients with recurrent or non recurrent disease

From: Promoter methylation of tumor suppressor genes in pre-neoplastic lesions; potential marker of disease recurrence

Gene ID

% R

% NR

Overall series

P

(Total = 31)

(Total = 47)

(Total = 78)

FHIT

38.71 (12/31)

2.13 (1/47)

16.67 (13/78)

3.1E-05

MLH1

25.81 (8/31)

2.13 (1/47)

11.54 (9/78)

0.002

ATM

22.58 (7/31)

2.13 (1/47)

10.26 (8/78)

0.006

TP73

35.48 (11/31)

12.77 (6/47)

21.79 (17/78)

0.025

BRCA1

9.68 (3/31)

0.00 (0/47)

3.85 (3/78)

0.059

CHFR

29.03 (9/31)

10.64 (5/47)

17.95 (14/78)

0.068

IGSF4

12.90 (4/31)

2.13 (1/47)

6.41 (5/78)

0.078

ESR1

70.97 (22/31)

85.11 (40/47)

79.49 (62/78)

0.158

DAPK1

22.58 (7/31)

10.64 (5/47)

15.38 (12/78)

0.203

CDKN2B

45.16 (14/31)

29.79 (14/47)

35.90 (28/78)

0.228

RASSF1 CpG1

41.94 (13/31)

29.79 (14/47)

34.62 (27/78)

0.333

RASSF1 CpG2

12.90 (4/31)

6.38 (3/47)

8.97 (7/78)

0.427

HIC1

16.13 (5/31)

8.51 (4/47)

11.54 (9/78)

0.471

CDKN2A

22.58 (7/31)

14.89 (7/47)

17.95 (14/78)

0.548

CASP8

6.45 (2/31)

2.13 (1/47)

3.85 (3/78)

0.560

CDH13

80.65 (25/31)

74.47 (35/47)

76.92 (60/78)

0.592

CD44

3.23 (1/31)

8.51 (4/47)

6.41 (5/78)

0.643

BRCA2

12.90 (4/31)

8.51 (4/47)

10.26 (8/78)

0.706

RARB

48.39 (15/31)

44.68 (21/47)

46.15 (36/78)

0.818

APC

45.16 (14/31)

48.94 (23/47)

47.44 (37/78)

0.819

TIMP3

38.71 (12/31)

36.17 (17/47)

37.18 (29/78)

1.000

CDKN1B

9.68 (3/31)

8.51 (4/47)

8.97 (7/78)

1.000

VHL

6.45 (2/31)

6.38 (3/47)

6.41 (5/78)

1.000

PTEN

3.23 (1/31)

4.26 (2/47)

3.85 (3/78)

1.000

  1. Abbreviations: R recurrent disease, NR non recurrent disease. P-value < 0.05.