Table 2 Prognostic factors for disease specific survival in 169 patients who underwent curative surgery

Age (≥65)

97

1.38

0.73 – 2.70

0.327

Gender (male)

128

1.27

0.60 – 2.49

0.517

Tumor location (distal)

107

0.42

0.22 – 0.78

0.006

0.53

0.27 – 1.05

0.067

Carcinoembryonic antigen (>5 ng/ml)

27

1.71

0.73 – 3.56

0.202

Carbohydrate antigen 19–9 (>37 IU/ml)

23

2.33

0.99 – 4.90

0.054

Tumor size (≥50 mm)

76

3.02

1.54 – 6.35

0.001

2.06

0.98 – 4.57

0.056

Tumor depth (pT4, UICC)

55

2.82

1.50 – 5.39

0.001

1.09

0.52 – 2.32

0.815

Tumor differentiation (undifferentiated)

89

1.79

0.93 – 3.60

0.081

Lymphatic involvement

137

5.70

1.74 – 35.2

0.002

1.12

0.14 – 6.12

0.905

Vessel invasion

83

4.10

2.02 – 9.20

<0.001

2.93

1.31 – 7.52

0.008*

Invasive growth

41

2.51

1.31 – 4.73

0.006

1.39

0.64 – 3.00

0.404

Lymph node metastasis

86

8.70

3.71 – 25.5

<0.001

4.01

1.40 – 14.6

0.008*

Expression of DPYSL-3 mRNA (high)

84

2.36

1.22 – 4.72

0.010

2.22

1.14 – 4.49

0.019*