Figure 7
From: MicroRNA-320c inhibits tumorous behaviors of bladder cancer by targeting Cyclin-dependent kinase 6
Forced expression of CDK6 partly rescued miR-320c-dependent suppression of tumorous behavior. The T24 cells were co-transfected with either miR-320c mimics or NC oligos with pTarget-CDK6 or empty pTarget vector. (A) The expression of CDK6 or GAPDH was detected by Western blot analysis. (B) Forced CDK6 expression partly attenuated the inhibitory effect of miR-320c on the colony formation rate. (C) Co-transfection of pCDK6 partially rescued miR-320c-induced inhibitory effect on cell invasion and migration (×200). (D) Forced expression of CDK6 significantly abrogated cell cycle arrest effect of miR-320c (*P < 0.05).