Figure 1

LKB1 immunohistochemistry staining in normal mammary and breast cancer tissues. Low-power (scale bar, 150 μm) and high-power (scale bar, 50 μm) photomicrographs showed (A) LKB1 localization in the cytoplasm of normal luminal epithelial cells, (B) strong LKB1 immunostaining in stageIbreast cancer tissues, (C) moderately positive LKB1 staining in stage IIbreast cancer tissues, (D) weakly positive LKB1 staining in stage III breast cancer tissues, (E) strong LKB1 immunostaining in ER/PR+++ breast cancer tissues, (F) weakly positive LKB1 immunostaining in ER/PR + breast cancer tissues, (G) strong LKB1 immunostaining in E-cadherin+++ breast cancer tissues, (H) negative LKB1 staining in E-cadherin breast cancer tissues, (I) strong LKB1 immunostaining in HMW-CK+++ breast cancer tissues, and (J) negative LKB1staining in HMW-CK breast cancer tissues.