Effect of siRNA PCGEM1 / pmiR-145 on prostate cancer xenografts. LNCaP tumor xenografts were established in male Athymic nude mice. Animals in the treatment arm received siRNA PCGEM1 (500 nM /kg once daily) or pmiR-145 (16 μg/kg once daily). Control mice received PBS (100 μl/kg once daily). Negative Control mice received empty plasmid or scrambled sequence (16 μg/kg once daily). After 20 daily treatments, tumors injected with siRNA PCGEM1 or pmiR-145 were significant smaller than control or NC group tumors (P△* < 0.05).