Figure 3
Effect of PPI treatment on otherwise untreated cells and on CTX treated cells. Presents an overview of the impact of esomeprazole treatment on otherwise untreated cells or on cells that were treated simultaneously with chemotherapeutics (3A: SCC; 3B: EAC). Tumour cells were treated with either esomeprazole alone at different concentrations (50 μM: “sub-lethal”, 86-100% cell survival; 250 μM: “lethal”, 20-30% cell survival; 350 μM: “highly lethal”, <10% cell survival), or with cisplatin or 5-FU at the respective LD50 concentrations, or with esomeprazole and chemotherapeutics together. The upper graphs present an overview of the relative cell survival of the respective groups (PPI treated cells versus chemotherapy (CTX) treated cells versus PPI + CTX treated cells). The lower graphs present an overview about the additional cytotoxic effect of PPI treatment on otherwise untreated cells (PPI w/o CTX) or on CTX treated cells (PPI w CTX). PPI: proton pump inhibitor esomeprazole. CTX: chemotherapy. *: statistically significant different compared to control.