Figure 6
From: SPOP suppresses tumorigenesis by regulating Hedgehog/Gli2 signaling pathway in gastric cancer
A working model. Gli2 is normally kept in the cytoplasm. We propose that SPOP may directly combine with Gli2 and the complex is recognized by ubiquitin. Then the ubiquitinated Gli2 encounters a proteasome-dependent degradation. Or SPOP acts to inhibit Gli2-mediated transcriptional activation and thereby block the effect of Gli2 on the activation of target genes, thus further impact on initiation of cancer cell proliferation, migration, invasion, and apoptosis.