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Table 1 Overall and stratified meta-analyses of the association between the EPHX1 Tyr113His polymorphism and cancer risk

From: Quantitative assessment of the influence of EPHX1 gene polymorphisms and cancer risk: a meta-analysis with 94,213 subjects

Variables Noa Case/control Homozygote comparison Heterozygote comparison Dominant model Recessive model Additive model
    OR (95% CI) P Pb(I2) OR (95% CI) P Pb(I2) OR (95% CI) P Pb(I2) OR (95% CI) P Pb(I2) OR (95% CI) P Pb(I2)
Total 45 20091/27396 1.05(0.95 ~ 1.16) 0.37 0.00(50.8) 0.94(0.88 ~ 1.01) 0.08 0.0(54.0) 0.96(0.90 ~ 1.03) 0.26 0.0(56.8) 1.08(0.99 ~ 1.18) 0.08 0.0(37.4) 1.00(0.95 ~ 1.05) 0.94 0.0(57.7)
Cancer type                  
Blood 7 2419/2319 1.05(0.76 ~ 1.46) 0.76 0.03(56.1) 0.89(0.73 ~ 1.01) 0.24 0.06(49.8) 0.92(0.75 ~ 1.13) 0.42 0.02(60.3) 1.17(0.96 ~ 1.41) 0.12 0.14(37.3) 0.97(0.82 ~ 1.15) 0.76 0.01(65.9)
Prostate 3 1706/1192 1.54(0.57 ~ 4.16) 0.86 0.00(88.9) 1.31(0.82 ~ 2.01) 0.26 0.00(79.7) 1.39(0.80 ~ 2.41) 0.24 0.00(87.1) 1.29(0.62 ~ 2.65) 0.50 0.0(82.2) 1.27(0.81 ~ 1.97) 0.30 0.00(89.7)
Esophageal 3 593/1086 1.09(0.78 ~ 1.51) 0.63 0.19(40.5) 1.01(0.52 ~ 1.93) 0.99 0.00(86.0) 1.08(0.63 ~ 1.84) 0.79 0.00(81.6) 1.16(0.85 ~ 1.58) 0.34 0.20(38.4) 1.09(0.84 ~ 1.41) 0.51 0.07(61.9)
Colorectal 9 5512/6787 0.98(0.86 ~ 1.11) 0.75 0.85(0.0) 1.00(0.93 ~ 1.08) 0.98 0.79(0.0) 0.99(0.93 ~ 1.07) 0.98 0.80(0.0) 0.98(0.87 ~ 1.11) 0.76 0.87(0.0) 1.00(0.94 ~ 1.05) 0.87 0.84(0.0)
Other 7 2425/2872 1.20(0.90 ~ 1.59) 0.22 0.06(50.4) 1.00(0.81 ~ 1.24) 0.99 0.01(66.7) 1.04(0.84 ~ 1.29) 0.74 0.00(69.4) 1.18(0.98 ~ 1.42) 0.08 0.40(2.8) 1.06(0.91 ~ 1.23) 0.45 0.01(65.5)
Lung 9 2065/5429 0.80(0.57 ~ 1.12) 0.20 0.00(62.5) 0.80(0.65 ~ 0.98) 0.03 0.00(65.0) 0.81(0.68 ~ 0.98) 0.03 0.01(62.5) 0.91(0.66 ~ 1.25) 0.57 0.01(61.7) 0.87(0.75 ~ 1.01) 0.08 0.0(65.5)
Head and neck 3 825/821 1.04(0.74 ~ 1.47) 0.81 0.98(0.0) 0.87(0.71 ~ 1.07) 0.19 0.82(0.0) 0.90(0.74 ~ 1.10) 0.30 0.85(0.0) 1.11(0.80 ~ 1.54) 0.53 0.99(0.0) 0.96(0.83 ~ 1.12) 0.61 0.91(0.0)
Breast cancer 4 4546/6890 1.02(0.90 ~ 1.17) 0.73 0.15(43.0) 0.99(0.91 ~ 1.07) 0.73 0.60(0.0) 0.99(0.92 ~ 1.07) 0.35 0.99(0.0) 1.14(0.89 ~ 1.46) 0.31 0.05(62.6) 1.00(0.97 ~ 1.03) 0.93 0.68(0.0)
Source of control                  
PB 31 16035/23111 1.03(0.93 ~ 1.14) 0.54 0.06(29.7) 0.97(0.92 ~ 1.03) 0.28 0.10(25.1) 0.98(0.93 ~ 1.04) 0.45 0.06(30.4) 1.03(0.96 ~ 1.11) 0.38 0.14(21.9) 1.00(0.95 ~ 1.04) 0.91 0.03(34.7)
HB 11 3517/3627 0.94(0.77 ~ 1.15) 0.56 0.08(40.9) 0.81(0.69 ~ 0.96) 0.01 0.00(59.4) 0.85(0.74 ~ 0.98) 0.03 0.03(49.4) 1.05(0.86 ~ 1.27) 0.66 0.05(45.7) 0.93(0.84 ~ 1.03) 0.16 0.05(45.3)
Ethnicity                  
Caucasian 26 11757/18447 0.94(0.87 ~ 1.03) 0.17 0.29(11.7) 0.93(0.87 ~ 1.00) 0.04 0.09(28.7) 0.93(0.87 ~ 1.00) 0.04 0.06(31.7) 0.97(0.89 ~ 1.05) 0.45 0.49(0.0) 0.96(0.91 ~ 1.00) 0.07 0.08(29.6)
Mixed 7 5645/5502 1.17(1.02 ~ 1.34) 0.03 0.42(0.7) 1.00(0.93 ~ 1.09) 0.96 0.57(0.0) 1.03(0.96 ~ 1.11) 0.44 0.53(0.0) 1.17(1.02 ~ 1.33) 0.02 0.44(0.0) 1.05(0.99 ~ 1.11) 0.11 0.43(0.0)
Asian 11 2534/3205 1.46(1.05 ~ 2.03) 0.04 0.00(75.1) 1.04(0.77 ~ 1.40) 0.81 0.00(81.7) 1.16(0.88 ~ 1.53) 0.30 0.00(56.8) 1.39(1.10 ~ 1.76) 0.01 0.01(60.7) 1.19(0.99 ~ 1.42) 0.05 0.0(79.4)
Smoking status                  
Smoker 9 1786/2114 0.99(0.80 ~ 1.23) 0.95 0.42(1.4) 0.85(0.66 ~ 1.10) 0.21 0.03(52.1) 0.89(0.71-1.11) 0.30 0.05(47.8) 1.07(0.87 ~ 1.31) 0.56 0.43(0.5) 0.97(0.88 ~ 1.08) 0.60 0.13(36.7)
Non-smoker 8 1357/1947 1.45(0.89 ~ 2.37) 0.14 0.00(71.4) 1.19(0.88 ~ 1.60) 0.27 0.01(63.6) 1.27(0.92 ~ 1.74) 0.14 0.00(71.7) 1.29(0.92~1.82) 0.14 0.05(50.0) 1.23(0.97 ~ 1.57) 0.09 0.00(75.8)
  1. PB: population based; HB: hospital based. Pb: P-values for heterogeneity from Q test; I2 refers to the proportion of total variation owing to between-study heterogeneity.
  2. Bold font marks where fixed effect model used.