Quantitative assessment of the influence of EPHX1 gene polymorphisms and cancer risk: a meta-analysis with 94,213 subjects

Yang, Xiaoqin; Wang, Yubing; Wang, Guiping

doi:10.1186/s13046-014-0082-9

Journal of Experimental & Clinical Cancer Research

Table 1 Overall and stratified meta-analyses of the association between the EPHX1 Tyr113His polymorphism and cancer risk

From: Quantitative assessment of the influence of EPHX1 gene polymorphisms and cancer risk: a meta-analysis with 94,213 subjects

Variables	No^a	Case/control	Homozygote comparison			Heterozygote comparison			Dominant model			Recessive model			Additive model
			OR (95% CI)	P	P^b(I²)	OR (95% CI)	P	P^b(I²)	OR (95% CI)	P	P^b(I²)	OR (95% CI)	P	P^b(I²)	OR (95% CI)	P	P^b(I²)
Total	45	20091/27396	1.05(0.95 ~ 1.16)	0.37	0.00(50.8)	0.94(0.88 ~ 1.01)	0.08	0.0(54.0)	0.96(0.90 ~ 1.03)	0.26	0.0(56.8)	1.08(0.99 ~ 1.18)	0.08	0.0(37.4)	1.00(0.95 ~ 1.05)	0.94	0.0(57.7)
Cancer type
Blood	7	2419/2319	1.05(0.76 ~ 1.46)	0.76	0.03(56.1)	0.89(0.73 ~ 1.01)	0.24	0.06(49.8)	0.92(0.75 ~ 1.13)	0.42	0.02(60.3)	1.17(0.96 ~ 1.41)	0.12	0.14(37.3)	0.97(0.82 ~ 1.15)	0.76	0.01(65.9)
Prostate	3	1706/1192	1.54(0.57 ~ 4.16)	0.86	0.00(88.9)	1.31(0.82 ~ 2.01)	0.26	0.00(79.7)	1.39(0.80 ~ 2.41)	0.24	0.00(87.1)	1.29(0.62 ~ 2.65)	0.50	0.0(82.2)	1.27(0.81 ~ 1.97)	0.30	0.00(89.7)
Esophageal	3	593/1086	1.09(0.78 ~ 1.51)	0.63	0.19(40.5)	1.01(0.52 ~ 1.93)	0.99	0.00(86.0)	1.08(0.63 ~ 1.84)	0.79	0.00(81.6)	1.16(0.85 ~ 1.58)	0.34	0.20(38.4)	1.09(0.84 ~ 1.41)	0.51	0.07(61.9)
Colorectal	9	5512/6787	0.98(0.86 ~ 1.11)	0.75	0.85(0.0)	1.00(0.93 ~ 1.08)	0.98	0.79(0.0)	0.99(0.93 ~ 1.07)	0.98	0.80(0.0)	0.98(0.87 ~ 1.11)	0.76	0.87(0.0)	1.00(0.94 ~ 1.05)	0.87	0.84(0.0)
Other	7	2425/2872	1.20(0.90 ~ 1.59)	0.22	0.06(50.4)	1.00(0.81 ~ 1.24)	0.99	0.01(66.7)	1.04(0.84 ~ 1.29)	0.74	0.00(69.4)	1.18(0.98 ~ 1.42)	0.08	0.40(2.8)	1.06(0.91 ~ 1.23)	0.45	0.01(65.5)
Lung	9	2065/5429	0.80(0.57 ~ 1.12)	0.20	0.00(62.5)	0.80(0.65 ~ 0.98)	0.03	0.00(65.0)	0.81(0.68 ~ 0.98)	0.03	0.01(62.5)	0.91(0.66 ~ 1.25)	0.57	0.01(61.7)	0.87(0.75 ~ 1.01)	0.08	0.0(65.5)
Head and neck	3	825/821	1.04(0.74 ~ 1.47)	0.81	0.98(0.0)	0.87(0.71 ~ 1.07)	0.19	0.82(0.0)	0.90(0.74 ~ 1.10)	0.30	0.85(0.0)	1.11(0.80 ~ 1.54)	0.53	0.99(0.0)	0.96(0.83 ~ 1.12)	0.61	0.91(0.0)
Breast cancer	4	4546/6890	1.02(0.90 ~ 1.17)	0.73	0.15(43.0)	0.99(0.91 ~ 1.07)	0.73	0.60(0.0)	0.99(0.92 ~ 1.07)	0.35	0.99(0.0)	1.14(0.89 ~ 1.46)	0.31	0.05(62.6)	1.00(0.97 ~ 1.03)	0.93	0.68(0.0)
Source of control
PB	31	16035/23111	1.03(0.93 ~ 1.14)	0.54	0.06(29.7)	0.97(0.92 ~ 1.03)	0.28	0.10(25.1)	0.98(0.93 ~ 1.04)	0.45	0.06(30.4)	1.03(0.96 ~ 1.11)	0.38	0.14(21.9)	1.00(0.95 ~ 1.04)	0.91	0.03(34.7)
HB	11	3517/3627	0.94(0.77 ~ 1.15)	0.56	0.08(40.9)	0.81(0.69 ~ 0.96)	0.01	0.00(59.4)	0.85(0.74 ~ 0.98)	0.03	0.03(49.4)	1.05(0.86 ~ 1.27)	0.66	0.05(45.7)	0.93(0.84 ~ 1.03)	0.16	0.05(45.3)
Ethnicity
Caucasian	26	11757/18447	0.94(0.87 ~ 1.03)	0.17	0.29(11.7)	0.93(0.87 ~ 1.00)	0.04	0.09(28.7)	0.93(0.87 ~ 1.00)	0.04	0.06(31.7)	0.97(0.89 ~ 1.05)	0.45	0.49(0.0)	0.96(0.91 ~ 1.00)	0.07	0.08(29.6)
Mixed	7	5645/5502	1.17(1.02 ~ 1.34)	0.03	0.42(0.7)	1.00(0.93 ~ 1.09)	0.96	0.57(0.0)	1.03(0.96 ~ 1.11)	0.44	0.53(0.0)	1.17(1.02 ~ 1.33)	0.02	0.44(0.0)	1.05(0.99 ~ 1.11)	0.11	0.43(0.0)
Asian	11	2534/3205	1.46(1.05 ~ 2.03)	0.04	0.00(75.1)	1.04(0.77 ~ 1.40)	0.81	0.00(81.7)	1.16(0.88 ~ 1.53)	0.30	0.00(56.8)	1.39(1.10 ~ 1.76)	0.01	0.01(60.7)	1.19(0.99 ~ 1.42)	0.05	0.0(79.4)
Smoking status
Smoker	9	1786/2114	0.99(0.80 ~ 1.23)	0.95	0.42(1.4)	0.85(0.66 ~ 1.10)	0.21	0.03(52.1)	0.89(0.71-1.11)	0.30	0.05(47.8)	1.07(0.87 ~ 1.31)	0.56	0.43(0.5)	0.97(0.88 ~ 1.08)	0.60	0.13(36.7)
Non-smoker	8	1357/1947	1.45(0.89 ~ 2.37)	0.14	0.00(71.4)	1.19(0.88 ~ 1.60)	0.27	0.01(63.6)	1.27(0.92 ~ 1.74)	0.14	0.00(71.7)	1.29(0.92~1.82)	0.14	0.05(50.0)	1.23(0.97 ~ 1.57)	0.09	0.00(75.8)

PB: population based; HB: hospital based. P^b: P-values for heterogeneity from Q test; I² refers to the proportion of total variation owing to between-study heterogeneity.
Bold font marks where fixed effect model used.

Back to article page

ISSN: 1756-9966

Contact us

Submission enquiries: Access here and click Contact Us
General enquiries: info@biomedcentral.com