Variables
|
Noa
|
Case/control
|
Homozygote comparison
|
Heterozygote comparison
|
Dominant model
|
Recessive model
|
Additive model
|
---|
| | |
OR (95% CI)
|
P
|
Pb(I2)
|
OR (95% CI)
|
P
|
Pb(I2)
|
OR (95% CI)
|
P
|
Pb(I2)
|
OR (95% CI)
|
P
|
Pb(I2)
|
OR (95% CI)
|
P
|
Pb(I2)
|
---|
Total
|
54
|
19437/27289
|
1.05(0.93 ~ 1.18)
|
0.73
|
0.09(21.3)
|
0.96(0.91 ~ 1.01)
|
0.15
|
0.02(31.5)
|
0.97(0.92 ~ 1.03)
|
0.30
|
0.00(40.1)
|
1.02(0.93 ~ 1.13)
|
0.66
|
0.23(12.0)
|
0.99(0.94 ~ 1.04)
|
0.57
|
0.00(44.9)
|
Cancer type
| | | | | | | | | | | | | | | | | |
Other
|
11
|
3160/4581
|
0.94(0.75 ~ 1.20)
|
0.64
|
0.53(0.0)
|
0.97(0.87 ~ 1.10)
|
0.51
|
0.56(0.0)
|
0.97(0.87 ~ 1.06)
|
0.47
|
0.53(0.0)
|
0.96(0.76 ~ 1.21)
|
0.71
|
0.53(0.0)
|
0.97(0.89 ~ 1.05)
|
0.50
|
0.46(0.0)
|
Blood
|
9
|
2929/3629
|
0.87(0.67 ~ 1.13)
|
0.29
|
0.90(0.0)
|
0.90(0.81 ~ 1.00)
|
0.05
|
0.25(21.4)
|
0.90(0.81 ~ 0.99)
|
0.04
|
0.47(0.0)
|
0.90(0.70 ~ 1.17)
|
0.44
|
0.82(0.0)
|
0.91(0.83 ~ 0.99)
|
0.04
|
0.80(0.0)
|
Esophageal
|
3
|
593/1081
|
1.30(0.50 ~ 3.38)
|
0.59
|
0.07(61.8)
|
1.02(0.65 ~ 1.62)
|
0.92
|
0.03(72.6)
|
1.06(0.66 ~ 1.73)
|
0.80
|
0.01(77.3)
|
1.30(0.54 ~ 3.13)
|
0.56
|
0.10(56.5)
|
1.10(0.71 ~ 1.69)
|
0.67
|
0.01(79.2)
|
Colorectal
|
10
|
5552/7089
|
1.14(0.85 ~ 1.53)
|
0.39
|
0.02(53.5)
|
0.92(0.85 ~ 0.99)
|
0.03
|
0.97(0.0)
|
0.94(0.87 ~ 1.01)
|
0.09
|
0.73(0.0)
|
1.17(0.87 ~ 1.58)
|
0.29
|
0.02(54.0)
|
0.97(0.91 ~ 1.03)
|
0.28
|
0.11(36.8)
|
Lung
|
14
|
4767/8411
|
1.14(0.83 ~ 1.56)
|
0.42
|
0.02(49.3)
|
1.10(0.94 ~ 1.27)
|
0.24
|
0.00(63.4)
|
1.10(0.93 ~ 1.29)
|
0.27
|
0.00(71.9)
|
0.97(0.80 ~ 1.17)
|
0.76
|
0.16(27.2)
|
1.07(0.93 ~ 1.24)
|
0.36
|
0.00(74.1)
|
Head and neck
|
4
|
1035/1075
|
1.28(0.81 ~ 2.02)
|
0.30
|
0.99(0.0)
|
0.84(0.70 ~ 1.01)
|
0.06
|
0.69(0.0)
|
0.88(0.73 ~ 1.05)
|
0.14
|
0.70(0.0)
|
1.35(0.85 ~ 2.13)
|
0.20
|
1.0(0.0)
|
0.94(0.81 ~ 1.01)
|
0.41
|
0.78(0.0)
|
Breast cancer
|
3
|
1401/1423
|
1.04(0.69 ~ 1.59)
|
0.85
|
0.49(0.0)
|
0.91(0.77 ~ 1.07)
|
0.04
|
0.66(0.0)
|
0.92(0.79 ~ 1.08)
|
0.30
|
0.67(0.0)
|
1.09(0.93 ~ 1.13)
|
0.70
|
0.49(0.0)
|
0.95(0.83 ~ 1.09)
|
0.44
|
0.66(0.0)
|
Source of control
| | | | | | | | | | | | | | | | | |
HB
|
16
|
5010/5638
|
1.14(0.93 ~ 1.41)
|
0.21
|
0.99(0.0)
|
0.96(0.88 ~ 1.05)
|
0.37
|
0.20(22.7)
|
0.98(0.90 ~ 1.06)
|
0.63
|
0.32(11.4)
|
1.17(0.95 ~ 1.44)
|
0.15
|
0.99(0.0)
|
1.00(0.94 ~ 1.08)
|
0.94
|
0.66(0.0)
|
PB
|
36
|
14191/21351
|
1.04(0.89 ~ 1.22)
|
0.61
|
0.01(39.4)
|
0.96(0.90 ~ 1.03)
|
0.22
|
0.01(39.4)
|
0.97(0.90 ~ 1.04)
|
0.40
|
0.00(50.7)
|
1.04(0.90 ~ 1.21)
|
0.56
|
0.05(30.0)
|
0.99(0.92 ~ 1.05)
|
0.64
|
0.00(57.2)
|
Ethnicity
| | | | | | | | | | | | | | | | | |
Asian
|
13
|
2957/3770
|
0.97(0.75 ~ 1.27)
|
0.84
|
0.51(0.0)
|
0.99(0.89 ~ 1.11)
|
0.90
|
0.26(18.6)
|
0.99(0.89 ~ 1.10)
|
0.88
|
0.14(30.6)
|
0.98(0.76 ~ 1.28)
|
0.90
|
0.59(0.0)
|
1.01(0.90 ~ 1.13)
|
0.90
|
0.09(37.1)
|
Caucasian
|
32
|
12294/17831
|
1.10(0.93 ~ 1.30)
|
0.26
|
0.03(34.8)
|
0.95(0.88 ~ 1.02)
|
0.18
|
0.01(44.0)
|
0.97(0.89 ~ 1.04)
|
0.39
|
0.00(52.8)
|
1.07(0.95 ~ 1.21)
|
0.27
|
0.11(24.4)
|
0.99(0.92 ~ 1.06)
|
0.71
|
0.00(57.3)
|
Mixed
|
7
|
3921/5262
|
0.90(0.73 ~ 1.12)
|
0.35
|
0.81(0.0)
|
0.94(0.86 ~ 1.04)
|
0.22
|
0.43(0.0)
|
0.94(0.86 ~ 1.03)
|
0.16
|
0.69(0.0)
|
0.92(0.74 ~ 1.14)
|
0.45
|
0.71(0.0)
|
0.95(0.88 ~ 1.02)
|
0.15
|
0.93(0.0)
|
African
|
2
|
265/426
|
0.81(0.22 ~ 2.96)
|
0.75
|
0.08(21.3)
|
1.09(0.79 ~ 1.50)
|
0.60
|
0.78(0.0)
|
1.06(0.78 ~ 1.45)
|
0.69
|
0.46(0.0)
|
0.78(0.23 ~ 2.73)
|
0.70
|
0.08(66.6)
|
1.03(0.94 ~ 1.01)
|
0.84
|
0.22(34.7)
|
Smoking status
| | | | | | | | | | | | | | | | | |
Smoker
|
9
|
2331/2542
|
1.08(0.64 ~ 1.83)
|
0.77
|
0.01(61.5)
|
1.19(0.88 ~ 1.60)
|
0.27
|
0.00(76.6)
|
1.16(0.85 ~ 1.58)
|
0.35
|
0.00(79.9)
|
1.04(0.68~1.60)
|
0.86
|
0.06(46.8)
|
1.09(0.84 ~ 1.41)
|
0.52
|
0.00(80.1)
|
Non-smoker
|
8
|
1498/2336
|
1.25(0.90 ~ 1.75)
|
0.19
|
0.67(0.0)
|
1.05(0.91 ~ 1.21)
|
0.49
|
0.78(0.0)
|
1.08(0.94 ~ 1.23)
|
0.30
|
0.71(0.0)
|
1.24(0.89 ~ 1.72)
|
0.21
|
0.71(0.0)
|
1.08(0.96 ~ 1.22)
|
0.19
|
0.60(0.0)
|
- PB: population based; HB: hospital based. Pb: P-values for heterogeneity from Q test; I2 refers to the proportion of total variation owing to between-study heterogeneity.
- Bold font marks where fixed effect model used.