Table 1 Oncolytic viruses in TMN clinical trials

Adenovirus

dsDNA

P53 (rAD-p53)

IT

Radioactive iodine/ Surgery

IV

24

P53 (ONYX-015)

IT

Cisplatin/5-fluorouracil

Marketed

27

Fas-c (VB-111)

IV

Anti-angiogenic agent

II

29

Reovirus

dsRNA

Natural strain (RT3D)

IT

Low-dose radiation/

II

35

IT/IV

Gemcitabine/Carboplatin/Paclitaxel/Docetaxel

III

37. 38

Herpes simplex virus

dsDNA

N/A

Vaccina virus

dsDNA

N/A

New castle disease virus

ssRNA

N/A

Vesicular virus

ssRNA

N/A

Measles virus

ssRNA

N/A

Retrovirus

ssRNA

N/A