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Table 1 Oncolytic viruses in TMN clinical trials

From: Progress in oncolytic virotherapy for the treatment of thyroid malignant neoplasm

Virus Genome Genetic alterations Delivery Combination Phase References
Adenovirus dsDNA P53 (rAD-p53) IT Radioactive iodine/ Surgery IV 24
   P53 (ONYX-015) IT Cisplatin/5-fluorouracil Marketed 27
   Fas-c (VB-111) IV Anti-angiogenic agent II 29
Reovirus dsRNA Natural strain (RT3D) IT Low-dose radiation/ II 35
    IT/IV Gemcitabine/Carboplatin/Paclitaxel/Docetaxel III 37. 38
Herpes simplex virus dsDNA N/A     
Vaccina virus dsDNA N/A     
New castle disease virus ssRNA N/A     
Vesicular virus ssRNA N/A     
Measles virus ssRNA N/A     
Retrovirus ssRNA N/A     
  1. Abbreviation:
  2. IT, Intra-tumor injection.
  3. IV, Intra-venous injection.