Figure 4

Concentration-response curves and drug-drug interaction analysis of combination treatment of MKN45, KATO-III, HT29-5F12, HT29-5M21 and LS174T cells. Left panel demonstrates left-sided shift of concentration-response curves of NAC after being used in combination with bromelain. Drug-drug interaction analysis (right panel) revealed synergism and additivity as the predominant patterns of interaction between bromelain and NAC in combination therapy.