Table 3 Association of combined expression status of SIRT1 and N1IC with clinicopathological parameters
From: Correlation and prognostic value of SIRT1 and Notch1 signaling in breast cancer
| Characteristics | N | SIRT1/N1IC | |||||
|---|---|---|---|---|---|---|---|
| High/low | Low/low | High/high | Low/high | χ 2 | p- value | ||
| N (%) | N (%) | N (%) | N (%) | ||||
| Age (years) | |||||||
| <50 | 74 | 12 (16.2) | 1 (1.4) | 44 (59.4) | 17 (23.0) | 6.027 | 0.110 |
| ≥50 | 76 | 22 (28.9) | 4 (5.3) | 37 (48.7) | 13 (17.1) | ||
| Lymph node metastasis | |||||||
| Absence | 83 | 18 (21.7) | 4 (4.8) | 48 (57.8) | 13 (15.7) | 3.664 | 0.300 |
| Presence | 67 | 16 (23.9) | 1 (1.5) | 33 (49.3) | 17 (25.4) | ||
| TNM stage | |||||||
| I-III | 128 | 30 (23.4) | 4 (3.1) | 69 (53.9) | 25 (19.5) | 0.441 | 0.932 |
| IV | 22 | 4 (18.2) | 1 (4.5) | 12 (54.5) | 5 (22.7) | ||
| Histological grade | |||||||
| 1 + 2 | 102 | 18 (17.6) | 4 (3.9) | 55 (53.9) | 25 (24.5) | 7.334 | 0.062 |
| 3 | 48 | 16 (33.3) | 1 (2.1) | 26 (54.2) | 5 (10.4) | ||
| ER status | |||||||
| Negative | 71 | 17 (23.9) | 2 (2.8) | 33 (46.5) | 19 (26.8) | 4.728 | 0.193 |
| Positive | 79 | 17 (21.5) | 3 (3.8) | 48 (60.8) | 11 (13.9) | ||
| PR status | |||||||
| Negative | 71 | 17 (23.9) | 2 (2.8) | 36 (50.7) | 16 (22.5) | 0.910 | 0.823 |
| Positive | 79 | 17 (21.5) | 3 (3.8) | 45 (57.0) | 14 (17.7) | ||
| HER2 status | |||||||
| Negative | 111 | 28 (25.2) | 4 (3.6) | 52 (46.8) | 27 (24.3) | 10.052 | 0.018* |
| Positive | 39 | 6 (15.4) | 1 (2.6) | 29 (74.4) | 3 (7.7) | ||
| Adjuvant therapy | |||||||
| Chemo | 75 | 17 (22.7) | 2 (2.7) | 43 (57.3) | 13 (17.3) | 17.431 | 0.042* |
| Chemo + radio | 15 | 2 (13.3) | 1 (6.7) | 7 (46.7) | 5 (33.3) | ||
| Chemo + radio + endocrine | 12 | 2 (16.7) | 1 (8.3) | 2 (16.7) | 7 (58.3) | ||
| Unknown | 48 | 13 (27.1) | 1 (2.1) | 29 (60.4) | 5 (10.4) | ||