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Table 4 Univariate Cox regression analysis for overall survival (OS) and disease-free survival (DFS) in 122 breast cancer patients

From: Correlation and prognostic value of SIRT1 and Notch1 signaling in breast cancer

Variables OS DFS
HR 95% CI p- value HR 95% CI p- value
Breast cancer patients (n =122)
Age (≥50 vs. <50) 1.631 0.676–3.935 0.277 1.611 0.688–3.888 0.288
Lymph node metastasis (presence vs. absence) 9.111 2.681–30.961 0.000* 9.123 2.685–30.997 0.000*
TNM stage (IV vs. 0–III) 6.851 2.901–16.180 0.000* 7.255 3.067–17.162 0.000*
Histological grade (3 vs. 1 + 2) 1.145 0.462–2.837 0.771 1.149 0.464–2.848 0.764
ER status (negative vs. positive) 0.338 0.131–0.871 0.025* 0.351 0.136–0.901 0.031*
PR status (negative vs. positive) 0.186 0.063–0.553 0.002* 0.191 0.064–0.566 0.003*
HER2 status (positive vs. negative) 0.657 0.241–1.793 0.412 0.646 0.237–1.763 0.393
SIRT1 expression (low vs. high) 0.278 0.118–0.657 0.004* 0.282 0.121–0.666 0.004*
N1IC expression (high vs. low) 1.395 0.469–4.145 0.549 1.394 0.469–4.142 0.551
Snail expression (high vs. low) 1.966 0.719–5.372 0.188 2.031 0.743–5.552 0.167
SIRT1/N1IC expression (high/low)   1 0.013   1 0.014
SIRT1/N1IC expression (low/low vs. high/low ) 0 0 0.985 0 0 0.985
SIRT1/N1IC expression (high/high vs. high/low) 0.693 0.203-2.368 0.559 0.692 0.203-2.366 0.557
SIRT1/N1IC expression (low/high vs. high/low) 3.278 1.025–10.481 0.045* 3.233 1.012–10.326 0.048*
  1. *P < 0.05.