From: Correlation and prognostic value of SIRT1 and Notch1 signaling in breast cancer
Variables | OS | DFS | ||||
---|---|---|---|---|---|---|
HR | 95% CI | p- value | HR | 95% CI | p- value | |
Breast cancer patients (n =122) | ||||||
Age (≥50 vs. <50) | 1.631 | 0.676–3.935 | 0.277 | 1.611 | 0.688–3.888 | 0.288 |
Lymph node metastasis (presence vs. absence) | 9.111 | 2.681–30.961 | 0.000* | 9.123 | 2.685–30.997 | 0.000* |
TNM stage (IV vs. 0–III) | 6.851 | 2.901–16.180 | 0.000* | 7.255 | 3.067–17.162 | 0.000* |
Histological grade (3 vs. 1 + 2) | 1.145 | 0.462–2.837 | 0.771 | 1.149 | 0.464–2.848 | 0.764 |
ER status (negative vs. positive) | 0.338 | 0.131–0.871 | 0.025* | 0.351 | 0.136–0.901 | 0.031* |
PR status (negative vs. positive) | 0.186 | 0.063–0.553 | 0.002* | 0.191 | 0.064–0.566 | 0.003* |
HER2 status (positive vs. negative) | 0.657 | 0.241–1.793 | 0.412 | 0.646 | 0.237–1.763 | 0.393 |
SIRT1 expression (low vs. high) | 0.278 | 0.118–0.657 | 0.004* | 0.282 | 0.121–0.666 | 0.004* |
N1IC expression (high vs. low) | 1.395 | 0.469–4.145 | 0.549 | 1.394 | 0.469–4.142 | 0.551 |
Snail expression (high vs. low) | 1.966 | 0.719–5.372 | 0.188 | 2.031 | 0.743–5.552 | 0.167 |
SIRT1/N1IC expression (high/low) | Â | 1 | 0.013 | Â | 1 | 0.014 |
SIRT1/N1IC expression (low/low vs. high/low ) | 0 | 0 | 0.985 | 0 | 0 | 0.985 |
SIRT1/N1IC expression (high/high vs. high/low) | 0.693 | 0.203-2.368 | 0.559 | 0.692 | 0.203-2.366 | 0.557 |
SIRT1/N1IC expression (low/high vs. high/low) | 3.278 | 1.025–10.481 | 0.045* | 3.233 | 1.012–10.326 | 0.048* |