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Table 4 Univariate Cox regression analysis for overall survival (OS) and disease-free survival (DFS) in 122 breast cancer patients

From: Correlation and prognostic value of SIRT1 and Notch1 signaling in breast cancer

Variables

OS

DFS

HR

95% CI

p- value

HR

95% CI

p- value

Breast cancer patients (n =122)

Age (≥50 vs. <50)

1.631

0.676–3.935

0.277

1.611

0.688–3.888

0.288

Lymph node metastasis (presence vs. absence)

9.111

2.681–30.961

0.000*

9.123

2.685–30.997

0.000*

TNM stage (IV vs. 0–III)

6.851

2.901–16.180

0.000*

7.255

3.067–17.162

0.000*

Histological grade (3 vs. 1 + 2)

1.145

0.462–2.837

0.771

1.149

0.464–2.848

0.764

ER status (negative vs. positive)

0.338

0.131–0.871

0.025*

0.351

0.136–0.901

0.031*

PR status (negative vs. positive)

0.186

0.063–0.553

0.002*

0.191

0.064–0.566

0.003*

HER2 status (positive vs. negative)

0.657

0.241–1.793

0.412

0.646

0.237–1.763

0.393

SIRT1 expression (low vs. high)

0.278

0.118–0.657

0.004*

0.282

0.121–0.666

0.004*

N1IC expression (high vs. low)

1.395

0.469–4.145

0.549

1.394

0.469–4.142

0.551

Snail expression (high vs. low)

1.966

0.719–5.372

0.188

2.031

0.743–5.552

0.167

SIRT1/N1IC expression (high/low)

 

1

0.013

 

1

0.014

SIRT1/N1IC expression (low/low vs. high/low )

0

0

0.985

0

0

0.985

SIRT1/N1IC expression (high/high vs. high/low)

0.693

0.203-2.368

0.559

0.692

0.203-2.366

0.557

SIRT1/N1IC expression (low/high vs. high/low)

3.278

1.025–10.481

0.045*

3.233

1.012–10.326

0.048*

  1. *P < 0.05.