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Table 5 Multivariate Cox regression analysis for overall survival (OS) and disease-free survival (DFS) in 122 breast cancer patients

From: Correlation and prognostic value of SIRT1 and Notch1 signaling in breast cancer

Variables OS DFS
  HR 95% CI p -value HR 95% CI p -value
Model 1 Breast cancer patients (n =122)       
LN metastasis (presence vs. absence) 9.078 2.269–36.322 2.269–36.322 0.002* 9.061 2.262–36.296 2.262–36.296 0.002*
TNM stage (IV vs. 0–III) 1.652 0.612–4.460 0.322 1.769 0.645–4.847 0.268
ER status (negative vs. positive) 1.193 0.347–4.101 0.779 1.130 0.332–3.845 0.845
PR status (negative vs. positive) 0.165 0.039–0.688 0.013* 0.179 0.043–0.752 0.019*
SIRT1 expression (low vs. high) 0.220 0.079–0.614 0.004* 0.207 0.074–0.58 0.003*
N1IC expression (high vs. low) 0.815 0.249–2.675 0.736 0.793 0.24–2.621 0.704
Snail expression (high vs. low) 1.189 0.639–5.174 0.262 1.938 0.677–5.551 0.218
Model 2 Breast cancer patients (n =122)       
LN metastasis (presence vs. absence) 7.913 2.002–31.286 0.003* 7.777 1.965–30.786 0.003*
TNM stage (IV vs. 0–III) 1.659 0.614–4.483 0.318 1.798 0.654–4.943 0.256
ER status (negative vs. positive) 1.203 0.353–4.093 0.768 1.152 0.342–3.882 0.819
PR status (negative vs. positive) 0.166 0.040–0.685 0.013* 0.180 0.043–0.749 0.018*
Snail expression (high vs. low) 1.901 0.667–5.418 0.229 2.031 0.709–5.821 0.187
SIRT1/N1IC expression (high/low)   1 0.023   1 0.016
SIRT1/N1IC expression (low/low vs. high/low) 0 0 0.986 0 0 0.987
SIRT1/N1IC expression (high/high vs. high/low) 0.695 0.202-2.395 0.564 0.665 0.191-2.317 0.522
SIRT1/N1IC expression (low/high vs. high/low) 3.519 1.031–12.01 0.045* 3.613 1.066–12.25 0.039*
  1. *P < 0.05.