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Table 5 Multivariate Cox regression analysis for overall survival (OS) and disease-free survival (DFS) in 122 breast cancer patients

From: Correlation and prognostic value of SIRT1 and Notch1 signaling in breast cancer

Variables

OS

DFS

 

HR

95% CI

p -value

HR

95% CI

p -value

Model 1 Breast cancer patients (n =122)

      

LN metastasis (presence vs. absence)

9.078

2.269–36.322 2.269–36.322

0.002*

9.061

2.262–36.296 2.262–36.296

0.002*

TNM stage (IV vs. 0–III)

1.652

0.612–4.460

0.322

1.769

0.645–4.847

0.268

ER status (negative vs. positive)

1.193

0.347–4.101

0.779

1.130

0.332–3.845

0.845

PR status (negative vs. positive)

0.165

0.039–0.688

0.013*

0.179

0.043–0.752

0.019*

SIRT1 expression (low vs. high)

0.220

0.079–0.614

0.004*

0.207

0.074–0.58

0.003*

N1IC expression (high vs. low)

0.815

0.249–2.675

0.736

0.793

0.24–2.621

0.704

Snail expression (high vs. low)

1.189

0.639–5.174

0.262

1.938

0.677–5.551

0.218

Model 2 Breast cancer patients (n =122)

      

LN metastasis (presence vs. absence)

7.913

2.002–31.286

0.003*

7.777

1.965–30.786

0.003*

TNM stage (IV vs. 0–III)

1.659

0.614–4.483

0.318

1.798

0.654–4.943

0.256

ER status (negative vs. positive)

1.203

0.353–4.093

0.768

1.152

0.342–3.882

0.819

PR status (negative vs. positive)

0.166

0.040–0.685

0.013*

0.180

0.043–0.749

0.018*

Snail expression (high vs. low)

1.901

0.667–5.418

0.229

2.031

0.709–5.821

0.187

SIRT1/N1IC expression (high/low)

 

1

0.023

 

1

0.016

SIRT1/N1IC expression (low/low vs. high/low)

0

0

0.986

0

0

0.987

SIRT1/N1IC expression (high/high vs. high/low)

0.695

0.202-2.395

0.564

0.665

0.191-2.317

0.522

SIRT1/N1IC expression (low/high vs. high/low)

3.519

1.031–12.01

0.045*

3.613

1.066–12.25

0.039*

  1. *P < 0.05.