From: Correlation and prognostic value of SIRT1 and Notch1 signaling in breast cancer
Variables | OS | DFS | ||||
---|---|---|---|---|---|---|
 | HR | 95% CI | p -value | HR | 95% CI | p -value |
Model 1 Breast cancer patients (n =122) | Â | Â | Â | Â | Â | Â |
LN metastasis (presence vs. absence) | 9.078 | 2.269–36.322 2.269–36.322 | 0.002* | 9.061 | 2.262–36.296 2.262–36.296 | 0.002* |
TNM stage (IV vs. 0–III) | 1.652 | 0.612–4.460 | 0.322 | 1.769 | 0.645–4.847 | 0.268 |
ER status (negative vs. positive) | 1.193 | 0.347–4.101 | 0.779 | 1.130 | 0.332–3.845 | 0.845 |
PR status (negative vs. positive) | 0.165 | 0.039–0.688 | 0.013* | 0.179 | 0.043–0.752 | 0.019* |
SIRT1 expression (low vs. high) | 0.220 | 0.079–0.614 | 0.004* | 0.207 | 0.074–0.58 | 0.003* |
N1IC expression (high vs. low) | 0.815 | 0.249–2.675 | 0.736 | 0.793 | 0.24–2.621 | 0.704 |
Snail expression (high vs. low) | 1.189 | 0.639–5.174 | 0.262 | 1.938 | 0.677–5.551 | 0.218 |
Model 2 Breast cancer patients (n =122) | Â | Â | Â | Â | Â | Â |
LN metastasis (presence vs. absence) | 7.913 | 2.002–31.286 | 0.003* | 7.777 | 1.965–30.786 | 0.003* |
TNM stage (IV vs. 0–III) | 1.659 | 0.614–4.483 | 0.318 | 1.798 | 0.654–4.943 | 0.256 |
ER status (negative vs. positive) | 1.203 | 0.353–4.093 | 0.768 | 1.152 | 0.342–3.882 | 0.819 |
PR status (negative vs. positive) | 0.166 | 0.040–0.685 | 0.013* | 0.180 | 0.043–0.749 | 0.018* |
Snail expression (high vs. low) | 1.901 | 0.667–5.418 | 0.229 | 2.031 | 0.709–5.821 | 0.187 |
SIRT1/N1IC expression (high/low) | Â | 1 | 0.023 | Â | 1 | 0.016 |
SIRT1/N1IC expression (low/low vs. high/low) | 0 | 0 | 0.986 | 0 | 0 | 0.987 |
SIRT1/N1IC expression (high/high vs. high/low) | 0.695 | 0.202-2.395 | 0.564 | 0.665 | 0.191-2.317 | 0.522 |
SIRT1/N1IC expression (low/high vs. high/low) | 3.519 | 1.031–12.01 | 0.045* | 3.613 | 1.066–12.25 | 0.039* |