Table 2 Univariate and multivariate Cox Regression Models for estimating the overall survival

Univariate analysis

Overall survival

Age (<60 y vs ≥60 y)

0.558

0.254 to 1.225

1.146

Gender (male vs female)

0.935

0.880 to 4.252

0.100

Alcohol history (nonsmoker vs smoker)

1.543

0.683 to 3.484

0.297

Smoking history (nonsmoker vs smoker)

1.481

0.699 to 3.137

0.305

Disease site

1.025

0.763 to 1.377

0.872

TNM stage

1.715

1.179 to 2.492

0.005

Lymph node metastasis (pN0 vs pN1 to pN2)

2.596

1.238 to 5.445

0.012

Pathological differentiation

2.294

1.448 to 3.634

0.001

PTHLH expression (low vs high)

0.022

0.003 to 0.159

<0.001

Multivariate analysis

Overall survival

PTHLH expression (low vs high)

0.024

0.003 to 0.180

<0.001

Pathological differentiation

2.156

1.268 to 3.666

0.005

Lymph node metastasis (pN0 vs pN1 to pN2)

1.100

0.423 to 2.861

0.845

TNM stage

1.193

0.730 to 1.949

0.482