Figure 4From: Pegylated arginine deiminase synergistically increases the cytotoxicity of gemcitabine in human pancreatic cancerPEG-ADI abrogates gemcitabine-mediated upregulation of RRM2 though E2F. A) Effect of PEG-ADI, gemcitabine or the combination on RRM2 protein levels in MIA-PaCa-2, PANC-1 and L3.3 cells, B) Effect of PEG-ADI, gemcitabine or the combination on hENT-1 protein levels in MIA-PaCa-2, PANC-1 and L3.3 cells.Back to article page