Figure 6

Immunohistochemical staining of MIA-PaCa-2 xenografts. MIA-PaCa-2 tumors treated with PBS (Control), ADI, gemcitabine or the combination (ADI + Gem) with immunohistochemical staining for RRM2, dCK, activated caspase 3 and TUNEL staining demonstrating the abrogation of gemcitabine-induced RRM2 with simultaneous ADI treatment. No treatment group had any significant effect on routine histology (H&E), dCK or cleaved caspase 3 levels or TUNEL staining.