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Table 4 Prognostic value of combined tumor/plasma KRAS status analyzed by PNA-PCR in a series of 242 metastatic colorectal cancer patients with matched samples

From: KRAS mutations in tumor tissue and plasma by different assays predict survival of patients with metastatic colorectal cancer

KRASstatus*

 

Median OS

  

Tumor/Plasma

No.

(mo)

95% Cl

Pvalue

Negative/Negative

113

21.0

19.226-22.774

0.008

Discordant

65

16.9

14.184-19.616

 

Positive/Positive

64

15.4

14.270-16.530

 
  1. *KRAS status was categorized as: negative, mutation-negative tumor and matched plasma samples; discordant, discordant KRAS status in tumor and matched plasma samples; positive, mutation-positive tumor tissue and matched plasma samples.
  2. CI, confidence interval; mo, month; OS, overall survival; PNA-PCR, peptide-nucleic-acid-mediated polymerase chain reaction clamping.