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Table 1 Sensitivity of lung cancer cell lines to CFZ and CDDP

From: Carfilzomib demonstrates broad anti-tumor activity in pre-clinical non-small cell and small cell lung cancer models

Cell line

CFZ IC50(μM)

CDDP IC50(μM)

48 h

72 h

96 h

48 h

72 h

96 h

NSCLC

      

H520

0.0769

0.0299

0.0083

19.43

23.24

18.15

A549

0.0901

0.0716

0.0047

25.97

26.53

9.01

H1993

0.0277

0.0172

0.0216

29.60

19.58

15.52

H460

0.1657

0.0631

0.0364

9.02

3.72

2.69

H1299

0.0500

0.0293

<0.0001

>30.0

8.81

3.53

SCLC

      

SHP77

0.0614

0.0994

0.2031

12.17

21.55

28.57

DMS114

0.0007

0.0002

<0.0001

13.13

8.10

3.47

  1. The determined inhibitory concentrations (IC50 values) represent the level of drug that inhibited cell growth by 50%. IC50 values (μM) of CFZ at 48 and 72 hours are the mean of two or more independent experiments, n ≥ 12. Other IC50 values are the mean of one experiment, n = 6.