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Figure 1 | Journal of Experimental & Clinical Cancer Research

Figure 1

From: Early B-cell factor 3 (EBF3) is a novel tumor suppressor gene with promoter hypermethylation in pediatric acute myeloid leukemia

Figure 1

Analysis of promoter methylation in pediatric AML by NimbleGen Human DNA Methylation arrays. Analysis of the methylation status of genes in five pediatric AML samples (M1, M2, M3, M4 and M5) and three NBM samples (N1, N2, and N3) using NimbleGen Human DNA Methylation arrays shows that the EBF3 promoter is significantly methylated in AML samples (5/5) and unmethylated in NBM samples (0/3). (A) Each red box represents the number of methylation peaks (PeakScore) overlapping the promoter region for the corresponding gene. The PeakScore is defined as the average -log10 (P value) from probes within the peak. (B) The scores reflect the probability of positive methylation enrichment.

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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