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Table 3 Association of EBF3 expression/promoter methylation with Kaplan-Meier survival in 105 pediatric AML samples

From: Early B-cell factor 3 (EBF3) is a novel tumor suppressor gene with promoter hypermethylation in pediatric acute myeloid leukemia

Variable

No. of patients

Over survival

P

Median ± SE

Cytogenetics

   

Favorable

50

46.664 ± 3.717

<0.001

Intermediate

27

29.220 ± 3.188

 

Unfavorable

28

11.161 ± 1.827

 

FAB

   

M1-M6

93

36.113 ± 2.885

<0.001

M7

12

8.542 ± 1.820

 

Leukocyte (/μl)

   

>10000

61

30.220 ± 2.974

0.803

≤10000

44

33.631 ± 4.063

 

MRD

   

<0.25%

49

53.627 ± 3.151

<0.001

≥0.25%

56

18.893 ± 2.425

 

EBF3 expression

   

Low < 12.11

52

38.971 ± 4.402

0.091

High ≥ 12.11

53

32.864 ± 3.654

 

EBF3 methylation

   

Negative

60

35.143 ± 3.509

0.190

Positive

45

29.458 ± 2.607

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