Table 5 Up-regulated genes in HL-60 cells treated with PLVX- EBF3 compared with control group

1

ANXA4

annexin A4

60.7992

65484.55

1077.063

0.000000

2

MTL5

metallothionein-like 5,

3327.433

78707.44

23.6541

0.004317

3

CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

477.7772

9830.082

20.57462

0.005702

4

PRLR

prolactin receptor

166.5942

3355.185

20.13987

0.00595

5

DCC

DCC netrin 1 receptor

60.97703

1106.082

18.13932

0.00733

6

AIFM2

apoptosis-inducing factor, mitochondrion-associated, 2

5221.303

76648.86

14.68003

0.01117

7

BIRC7

baculoviral IAP repeat containing 7

10810.86

134973.2

12.48496

0.01541

8

APOE

apolipoprotein E

1234.913

15389.71

12.46218

0.015466

9

FAIM

Fas apoptotic inhibitory molecule

59.72215

723.2259

12.10985

0.016371

10

BCL6

B-cell CLL/lymphoma 6

300.2861

3465.696

11.54131

0.018009

11

EEF1A2

eukaryotic translation elongation factor 1 alpha 2

3430991

34629902

10.09326

0.023482

12

DAPK1

death-associated protein kinase 1

36.00672

341.4206

9.482138

0.026565

13

DAPK2

death-associated protein kinase 2

106.9056

926.7119

8.668504

0.031703

14

CUL-5

cullin 5

1607.044

10876.05

6.767734

0.021489

15

CARD10

caspase recruitment domain family, member 10

736432.7

4740088

6.436553

0.03677

16

HTATIP2

HIV-1 Tat interactive protein 2

21030.48

125463.2

5.965781

0.006577

17

HSPA1B

heat shock 70 kDa protein 1B

9411.403

51996.48

5.524838

0.046279

18

EIF2AK3

eukaryotic translation initiation factor 2-alpha kinase 3

1296.309

6741.561

5.200581

0.035667

19

PTH

parathyroid hormone

3.364038

14.63482

4.350374

0.020214

20

FAS

Fas cell surface death receptor

278.2416

1168.472

4.199489

0.028443

21

PPP2CA

protein phosphatase 2, catalytic subunit

19486.59

77413.57

3.972658

0.012455

22

GFRAL

GDNF family receptor alpha like

2.948935

11.44733

3.881851

0.018696

23

CBX4

chromobox homolog 4

12247.45

47277.53

3.860193

0.010244

24

Bcl2-A1

BCL2-related protein A1

191.3664

733.6087

3.833528

0.012181

25

CASP7

caspase 7, apoptosis-related cysteine peptidase

3214.089

11901.59

3.702944

0.012218

26

AIFM3

apoptosis-inducing factor, mitochondrion-associated, 3

2320.458

8123.495

3.500815

0.019759

27

TNFAIP3

tumor necrosis factor, alpha-induced protein 3

396.2299

1312.111

3.311488

0.018799

28

PRODH

proline dehydrogenase (oxidase) 1

1017.064

3162.695

3.109634

0.022482

29

BIK

BCL2-interacting killer (apoptosis-inducing)

3304.449

10077.62

3.049712

0.020294

30

CFL1

cofilin 1

96630.71

284065.3

2.9397

0.024696

31

PIK3CA

phosphatidylinositol-4,5-bisphosphate 3-kinase

1192.848

3307.876

2.773091

0.027971

32

SERPINB2

serpin peptidase inhibitor, clade B

324.0773

898.5624

2.77268

0.022041

33

DAP3

death associated protein 3

59483.18

156832.7

2.636589

0.029577

34

MSH6

mutS homolog 6

10961.78

26493.5

2.416898

0.033269

35

XIAP

X-linked inhibitor of apoptosis

680.3787

1616.734

2.376227

0.033028

36

PRKRA

protein kinase, interferon-inducible double stranded RNA dependent activator

6339.679

15064.52

2.376227

0.035028

37

CD28

CD28 molecule

60.97703

140.9465

2.311469

0.039382

38

DEDD

death effector domain containing

10588.38

24135.46

2.27943

0.037863

39

CUL4A

cullin 4A

43243.45

98570.4

2.27943

0.037863

40

ERN1

endoplasmic reticulum to nucleus signaling 1

786.986

1766.819

2.245046

0.038268

41

PMAIP1

phorbol-12-myristate-13-acetate-induced protein 1

3492.862

7820.367

2.238957

0.038967

42

API5

apoptosis inhibitor 5

12078.84

26298.57

2.177243

0.040781

43

CHEK2

checkpoint kinase 2

11995.4

26047.67

2.171471

0.040504

44

CIDEC

cell death-inducing DFFA-like effector c

401.7611

872.4127

2.171471

0.040804

45

BAG3

BCL2-associated athanogene 3

6889.55

14849.39

2.155349

0.041371

46

CFLAR

CASP8 and FADD-like apoptosis regulator

1746.431

3747.656

2.145894

0.046262

47

TNFRSF19

tumor necrosis factor receptor superfamily, member 19

64.45383

136.2673

2.114186

0.042161

48

CASP5

caspase 5, apoptosis-related cysteine peptidase

439.6446

922.1559

2.097503

0.043498

49

MAPK8IP2

mitogen-activated protein kinase 8 interacting protein 2

200.8806

416.1298

2.071529

0.049992

50

BIRC3

baculoviral IAP repeat containing 3

129.8043

268.4701

2.068268

0.044074

51

BNIP3

BCL2/adenovirus E1B 19 kDa interacting protein 3

53609.24

110136

2.054421

0.044571

52

DPF2

D4, zinc and double PHD fingers family 2

40910.8

84044.57

2.054337

0.045739

53

HMGB-1

high mobility group box 1

299084.6

610176.4

2.040147

0.045059

54

CFDP1

craniofacial development protein 1

6517.912

13297.5

2.040147

0.045059

55

HDAC-1

histone deacetylase 1

75291.22

153605.1

2.040147

0.045559

56

CYCS

cytochrome c, somatic

6472.889

13109.45

2.025285

0.045684

57

NLRP1

NLR family, pyrin domain containing 1

32772.41

66367.88

2.025115

0.045743

58

BCLAF1

BCL2-associated transcription factor 1

10227.7

20698.39

2.023758

0.045215

59

DDX20

DEAD (Asp-Glu-Ala-Asp) box polypeptide 20

9090.816

18355.6

2.019137

0.045827

60

IKBIP

IKBKB interacting protein

3327.433

6694.993

2.012059

0.040311

61

EDAR

ectodysplasin A receptor

1090.062

2191.093

2.010063

0.046015

62

MAPK8

mitogen-activated protein kinase 8

8842.227

17718

2.003793

0.043235