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Table 2 Selection analysis for the K1 gene of HHV-8 showing the effect of molecular sequence variation on amino-acid substitution

From: Analysis of the ORFK1 hypervariable regions reveal distinct HHV-8 clustering in Kaposi’s sarcoma and non-Kaposi’s cases

Negatively selected sites*

102(Gln)

  

(ω <1)**

   

HYPHY software

   

Positively selected sites*

44 (Glu,Ala,Thr,His,Ser,Pro)

58 (Ser,Phe,Trp,Leu,Val)

60 (Leu,Pro,Met,Ala)

(ω >1) **

62 (Gln, Asp, Lys,Glu,Thr,Arg)

66 (Leu,Phe,Thr,Asn,Ser,His)

66 (Leu,Phe,Thr,Asn,Ser,His)

HYPHY and PAML software

67 (Val,Pro,Ala,Gly,Ile)

68 (Gly,Val,Ala,Ser,Leu,Phe,Asp)

69 (Thr,Asp,Arg,Asn,Ile)

 

70 (Ile,Phe,Leu)

71 (Ile,Ser,Val,Asn,Ala,Thr,His)

75 (Val,Thr,Ser,Leu)

 

101 (Gly,Ala,Val,Arg)

  
  1. *Negatively selected sites and Positively selected sites are numbered according to amino acid position of K1 of HHV-8 Virus isolate accession number DQ394068.
  2. **ω = dN/dS ratio of divergence at non-synonymous (nucleotide sites at which substitution causes an amino-acid change) and synonymous sites (nucleotide sites at which substitution does not causes an amino-acid change).
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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