Characterization of genome-wide TFCP2 targets in hepatocellular carcinoma: implication of targets FN1 and TJP1 in metastasis

Table 1 Bio-function analysis of the TFCP2-regulated genes in HepG2 knock down of TFCP2

Category	Functions	P -Value	Activation State ^†	z-score ^†	#Molecules ^§
Cancer	Growth	2.81E-07		−0.508	28
Cellular assembly and organization	Adhesion	5.47E-07			11
Cell-To-Cell Signaling and Interaction	Binding	1.15E-06	Decreased	−2.412	6
Cardiovascular System Development and Function	Angiogenesis	1.22E-05	Decreased	−2.297	32
Cellular Movement	Cell movement of carcinoma cell lines	6.24E-05	Decreased	−2.252	11
Cell-To-Cell Signaling and Interaction	Attachment of cells	1.93E-04	Decreased	−2.412	7
Cellular Movement	Chemotaxis of tumor cell lines	1.17E-03	Decreased	−2.036	10

^†Activation State & z-score, z-score was calculated by the IPA z-score algorithm, reflecting the predicted direction of change for the function, an absolute z-score of ≥ 2 is considered significant. Activation State is: Increased if the z-score is ≥ 2, Decreased if the z-score ≤ −2, Blank (empty) - IPA does not make a prediction for the process or disease. ^§The number of molecules (genes) that are associated with each function.

ISSN: 1756-9966