Table 1 Clinical characteristics of patient groups

Mean age at ovarian cancer diagnosis in years (range)

48.8 (16.9-70.6)

51.2 (33.8-66.9)

Mean age at breast cancer diagnosis in years (range)

48.1 (25.0-72.9)

BRCA1 mutation status

• Negative

198 (88.0%)

46 (71.9%)

• Positive

27 (12.0%)

18 (28.1%)

BRCA1 mutation type

• 5382insC (c.5266dupC)

17 (63.0%)

14 (77.8%)

• 300 T/G (c.181 T > G)

8 (29.6%)

2 (11.1%)

• 185delAG (c.68-69delAG)

2 (7.4%)

2 (11.1%)

• 4153delA (c. 4034delA)

--

--

• 3819del5 (c.3700_3704del5)

--

--

FIGO

• I

73 (32.4%)

16 (25.0%)

• II

33 (14.7%)

5 (7.8%)

• III

95 (42.2%)

31 (48.5%)

• IV

13 (5.8%)

2 (3.1%)

• Unspecified/unknown

11 (4.9%)

10 (15.6%)

GRADE

• G1- well differentiated

34 (15.1%)

3 (4.7%)

• G2- moderately differentiated

98 (43.6%)

20 (31.2%)

• G3- undifferentiated

86 (38.2%)

29 (45.3%)

• G4

1 (0.4%)

--

• unspecified/unknown

6 (2.7)

12 (18.8%)

Histology

• Serous

121 (53.8%)

41 (64.1%)

• Mucinous

23 (10.2%)

2 (3.1%)

• Endometrioid

33 (14.7%)

2 (3.1%)

• Clear cell

6 (2.7%)

1 (1.6%)

• Other/unspecified

41 (18.2%)

15 (23.4%)

• Unknown

1 (0.4%)

3 (4.7%)

GRADE

• G1- well differentiated

10 (15.6%)

• G2- moderately differentiated

22 (34.4%)

• G3- undifferentiated

6 (9.4%)

• Unspecified/unknown

26 (40.6%)

Histology

• Ductal carcinoma in situ

1 (1.6%)

• Ductal carcinoma

44 (68.7%)

• Lobular carcinoma

1 (1.6%)

• Medullary carcinoma

3 (4.7%)

• Other

13 (20.3%)

• Unspecified

2 (3.1%)