Table 2 Case–control analyses of ovarian and breast and ovarian cancer risk
| Â | Â | Â | Ovarian cancer all patients | Ovarian cancer BRCA1 - | Ovarian cancer BRCA1 + | Breast and ovarian cancer | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene polymorphism | Genotype | Controls n(%) | n(%) | OR (±95% CI) | p | n(%) | OR (±95% CI) | p | n(%) | OR (±95% CI) | p | n(%) | OR (±95% CI) | p |
PGR p.Val660Leu rs1042838 | GG | 239 (69.3) | 143 (63.9) | 1(ref) | Â | 131 (66.5) | 1(ref) | Â | 12 (44.4) | 1(ref) | Â | 46 (75.4) | 1 (ref) | Â |
GT | 95 (27.5) | 74 (33.0) | 1.03 (0.90-1.88) | 0.160 | 60 (30.5) | 1.15 (0.78-1.70) | 0.473 | 14 (51.9) | 2.94 (1.31-6.58) | 0.009 | 14 (23.0) | 0.77 (0.40-1.46) | 0.416 | |
TT | 11 (3.2) | 7 (3.1) | 1.06 (0.40-2.81) | 0.901 | 6 (3.0) | 1.00 (0.36-2.75) | 0.993 | 1 (3.70) | 1.81 (0.22-15.20) | 0.584 | 1 (1.6) | 0.47 (0.06-3.75) | 0.478 | |
GT + TT | 106 (30.7) | 81 (36.1) | 1.20 (0.88-1.63) | 0.249 | 66 (33.5) | 1.14 (0.78-1.65) | 0.504 | 15 (55.6) | 2.82 (1.28-6.23) | 0.010 | 15 (24.6) | 0.74 (0.39-1.38) | 0.336 | |
ABCB1 p.Ser893Ala p.Ser893Thr rs2032582 | GG | 117 (33.7) | 65 (29.0) | 1(ref) | Â | 56 (28.4) | 1(ref) | Â | 9 (33.4) | 1(ref) | Â | 16 (26.2) | 1 (ref) | Â |
GT | 156 (45.0) | 115 (51.4) | 1.33 (0.90-1.95) | 0.152 | 104 (52.8) | 1.39 (0.93-2.09) | 0.108 | 11 (40.7) | 0.92 (0.37-2.28) | 0.852 | 33 (54.1) | 1.55 (0.71-2.94) | 0.184 | |
TT | 60 (17.3) | 37 (16.5) | 1.11 (0.67-1.85) | 0.688 | 32 (16.3) | 1.11 (0.65-1.90) | 0.691 | 5 (18.5) | 1.08 (0.35-3.38) | 0.890 | 9 (14.8) | 1.10 (0.46-2.63) | 0.836 | |
GA | 9 (2.6) | 2 (0.9) | 0.40 (0.08-1.91) | 0.250 | 2 (1.0) | 0.46 (0.10-2.24) | 0.337 | -- | -- | -- | 2 (3.3) | 1.63 (0.32-8.31) | 0.557 | |
TA | 5 (1.4) | 5 (2.2) | 1.80 (0.50-6.45) | 0.367 | 3 (1.5) | 1.25 (0.29-5.49) | 0.763 | 2 (7.4) | 5.20 (0.87-31.18) | 0.069 | 1 (1.6) | 1.46 (0.16-13.6) | 0.736 | |
AA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | |
GG + GT + GA | 282 (81.3) | 182 (81.3) | 1 (ref) |  | 162 (82.2) | 1 (ref) |  | 20 (74.1) | 1 (ref) |  | 51 (83.6) | 1 (ref) |  | |
TT + TA | 65 (18.7) | 42 (18.7) | 1.00 (0.92-1.09) | 1.000 | 35 (17.8) | 0.94 (0.60-1.48) | 0.780 | 7 (25.9) | 1.52 (0.61-3.76) | 0.364 | 10 (16.4) | 0.85 (0.41-1.77) | 0.664 | |
ABCB1 p.Ile1145= rs1045642 | CC | 83 (24.0) | 44 (19.6) | 1(ref) | Â | 35 (17.8) | 1(ref) | Â | 9 (33.3) | 1(ref) | Â | 16 (26.2) | 1 (ref) | Â |
CT | 162 (47.0) | 122 (54.5) | 1.42 (0.92-2.19) | 0.113 | 112 (56.8) | 1.64 (1.03-2.60) | 0.036 | 10 (37.1) | 0.57 (0.22-1.46) | 0.239 | 26 (42.6) | 0.83 (0.42-1.64) | 0.596 | |
TT | 100 (29.0) | 58 (25.9) | 1.09 (0.67-1.78) | 0.718 | 50 (25.4) | 1.18 (0.70-2.00) | 0.522 | 8 (29.6) | 0.74 (0.27-2.00) | 0.549 | 19 (31.2) | 0.98 (0.48-2.04) | 0.969 | |
CT + TT | 262 (76.0) | 180 (80.4) | 1.02 (0.81-1.30) | 0.827 | 162 (82.2) | 1.47 (0.94-2.28) | 0.089 | 18 (66.7) | 0.63 (0.27-1.46) | 0.285 | 45 (73.8) | 0.89 (0.48-1.66) | 0.716 | |
ABCG2 p.Gln141Lys rs2231142 | CC | 276 (80.2) | 191 (86.4) | 1 (ref) | Â | 167 (85.6) | 1 (ref) | Â | 24 (92.3) | 1 (ref) | Â | 56 (87.5) | 1 (ref) | Â |
CA | 68 (19.8) | 30 (13.6) | 0.64 (0.40-1.02) | 0.059 | 28 (14.4) | 0.68 (0.42–1.10) | 0.116 | 2 (7.7) | 0.34 (0.08–0.47) | 0.147 | 8 (12.5) | 0.58 (0.26–1.28) | 0.175 | |
ATM p.Asp1853Asn rs1801516 | GG | 254 (75.8) | 153 (68.6) | 1 (ref) | Â | 134 (68.4) | 1 (ref) | Â | 19 (70.4) | 1 (ref) | Â | 45 (70.3) | 1 (ref) | Â |
GA | 76 (22.7) | 64 (28.7) | 1.40 (0.95-2.06) | 0.091 | 57 (29.1) | 1.42 (0.95-2.13) | 0.083 | 7 (25.9) | 1.23 (0.50-3.05) | 0.651 | 15 (23.4) | 1.11 (0.59-2.11) | 0.740 | |
AA | 5 (1.5) | 6 (2.7) | 1.99 (0.60-6.66) | 0.262 | 5 (2.5) | 1.90 (0.54-6.69) | 0.319 | 1 (3.7) | 2.67 (0.39-24.29) | 0.380 | 4 (6.3) | 4.52 (1.16-17.56) | 0.029 | |
GA + AA | 81 (24.2) | 70 (31.4) | 1.43 (0.98-2.09) | 0.061 | 62 (31.6) | 1.45 (0.98-2.15) | 0.062 | 8 (29.6) | 1.32 (0.73-2.40) | 0.352 | 19 (29.7) | 1.32 (0.56-3.14) | 0.528 | |
TP53 p.Arg72Pro rs1042522 | GG | 167 (49.0) | 130 (57.8) | 1 (ref) | Â | 115 (58.1) | 1 (ref) | Â | 15 (55.6) | 1 (ref) | Â | 29 (48.3) | 1 (ref) | Â |
GC | 150 (44.0) | 79 (35.1) | 0.68 (0.47-0.97) | 0.031 | 70 (35.3) | 0.68 (0.47-0.98) | 0.039 | 9 (33.3) | 0.67 (0.28-1.57) | 0.355 | 29 (48.3) | 1.11 (0.64-1.95) | 0.707 | |
CC | 24 (7.0) | 16 (7.1) | 0.86 (0.44-1.68) | 0.652 | 13 (6.6) | 0.79 (0.39-1.61) | 0.511 | 3 (11.1) | 1.39 (0.38-5.16) | 0.621 | 2 (3.3) | 0.48 (0.11-2.14) | 0.336 | |
GC + CC | 174 (51.0) | 95 (42.2) | 0.80 (0.61-1.05) | 0.104 | 83 (41.9) | 0.69 (0.49-0.99) | 0.042 | 12 (44.4) | 0.77 (0.35-1.69) | 0.511 | 31 (51.67) | 1.03 (0.59-1.78) | 0.927 | |
ATP7B p.Ser406Ala rs1801243 | TT | 103 (30.8) | 41 (19.0) | 1 (ref) | Â | 35 (18.5) | 1 (ref) | Â | 6 (22.2) | 1 (ref) | Â | 13 (20.3) | 1 (ref) | Â |
TG | 157 (47.0) | 113 (52.3) | 1.81 (1.17-2.80) | 0.008 | 100 (52.9) | 1.87 (1.18-2.97) | 0.007 | 13 (48.2) | 1.42 (0.52-3.88) | 0.490 | 32 (50.0) | 1.61 (0.81-3.23) | 0.174 | |
GG | 74 (22.2) | 62 (28.7) | 2.10 (1.28-3.46) | 0.003 | 54 (28.6) | 2.15 (1.27-3.62) | 0.004 | 8 (29.6) | 1.86 (0.61-5.61) | 0.270 | 19 (29.7) | 2.03 (0.94-4.40) | 0.069 | |
TG + GG | 231 (69.2) | 175 (81.0) | 1.90 (1.26-2.88) | 0.002 | 154 (81.5) | 1.96 (1.27-3.03) | 0.002 | 21 (77.8) | 1.56 (0.61-3.99) | 0.352 | 51 (79.7) | 1.75 (0.91-3.36) | 0.093 | |
ATP7B p.Arg952Lys rs732774 | AA | 103 (30.7) | 86 (38.9) | 1 (ref) | Â | 76 (39.2) | 1 (ref) | Â | 10 (37.0) | 1 (ref) | Â | 25 (39.7) | 1 (ref) | Â |
AG | 159 (47.5) | 96 (43.4) | 0.72 (0.49-1.06) | 0.096 | 82 (42.3) | 0.70 (0.47-1.04) | 0.078 | 14 (51.9) | 0.91 (0.39-2.11) | 0.821 | 31 (49.2) | 0.80 (0.45-1.44) | 0.471 | |
GG | 73 (21.8) | 39 (17.7) | 0.64 (0.39-1.04) | 0.070 | 36 (18.5) | 0.67 (0.41-1.10) | 0.112 | 3 (11.1) | 0.42 (0.11-1.61) | 0.203 | 7 (11.1) | 0.40 (0.16-0.97) | 0.041 | |
AG + GG | 232 (69.3) | 135 (61.1) | 0.70 (0.49-1.00) | 0.047 | 118 (60.8) | 0.69 (0.48-1.00) | 0.049 | 17 (63.0) | 0.75 (0.33-1.71) | 0.499 | 38 (60.3) | 0.67 (0.39-1.18) | 0.165 | |
GST T1/M1 Gene deletions | wt/wt | 118 (34.6) | 82 (36.8) | 1(ref) | Â | 72 (36.7) | 1(ref) | Â | 10 (37.0) | 1(ref) | Â | 20 (31.3) | 1(ref) | Â |
wt/null | 49 (14.4) | 18 (8.1) | 0.53 (0.29-0.98) | 0.040 | 17 (8.7) | 0.57 (0.30-1.07) | 0.076 | 1 (3.7) | 0.24 (0.03-1.96) | 0.180 | 6 (9.4) | 0.72 (0.27-1.92) | 0.512 | |
null/wt | 138 (40.5) | 95 (42.6) | 0.99 (0.64-1.54) | 0.967 | 82 (41.8) | 0.97 (0.65-0.47) | 0.90 | 13 (48.2) | 1.11 (0.47-2.64) | 0.810 | 31 (48.4) | 1.32 (0.72-2.45) | 0.368 | |
null/null | 36 (10.5) | 28 (12.5) | 1.12 (0.63-1.98) | 0.698 | 25 (12.8) | 1.14 (0.63-2.06) | 0.667 | 3 (11.1) | 0.98 (0.24-4.04) | 0.982 | 7 (10.9) | 1.14 (0.45-2.95) | 0.774 | |
GSTP1 p.Ile105Val rs1695 | AA | 151 (45.2) | 104 (46.4) | 1 (ref) | Â | 93 (47.2) | 1 (ref) | Â | 11 (40.7) | 1 (ref) | Â | 32 (52.4) | 1 (ref) | Â |
AG | 162 (48.5) | 95 (42.4) | 0.85 (0.60-1.22) | 0.376 | 84 (42.6) | 0.84 (0.58-1.22) | 0.361 | 11 (40.7) | 0.93 (0.39-2.22) | 0.873 | 36 (36.1) | 0.64 (0.36-1.15) | 0.137 | |
GG | 21 (6.3) | 25 (11.2) | 1.73 (0.92-3.26) | 0.090 | 20 (10.2) | 1.54 (0.79-3.01) | 0.199 | 5 (18.6) | 3.27 (1.03-10.42) | 0.044 | 7 (11.5) | 1.57 (0.61-4.03) | 0.342 | |
AG + GG | 183 (54.8) | 120 (53.6) | 0.95 (0.68-1.34) | 0.776 | 104 (52.8) | 0.92 (0.65-1.32) | 0.656 | 16 (49.3) | 1.20 (0.54-2.67) | 0.653 | 43 (47.6) | 0.75 (0.43-1.29) | 0.296 | |