Figure 4

Knockdown of Rap1A suppresses growth, adhesion and invasion of PCa cells. (A) PC-3 and DU145 cells were transfected with shRNA for Rap1A (shRap1A) or shRNA-negative controls. The Rap1A protein was analyzed by Western blotting. Cell growth (B), cell adhesion (C), and invasion assays (D) were performed with Rap1A silencing. * p < 0.05, ** p < 0.01.