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Table 1 Cell viabilities of GBM cells and non-cancerous cells after treatments with PENAO, DCA and combination

From: Dual-targeting of aberrant glucose metabolism in glioblastoma

Compounds IC 50 values
GBM cell lines Non-canerous cell lines
U87 U251 DBTRG LN229 BAH1 MRC-5 Normal human astrocytes
PENAO ( μM) 3.5 ± 0.5 2.5 ± 0.4 3.5 ± 0.2 3.0 ± 0.4 3.4 ± 0.3 8.7 ± 0.7 7.9 ± 1.2
DCA (mM) 25.6 ± 6.2 24.3 ± 5.7 28.2 ± 4.5 40.3 ± 5.2 46.5 ± 6.2 n.d. n.d.
  1. The half maximal inhibitory concentration (IC50) values were determined by MTS assay at 72 hr time point for all drug treatments. Values are mean ± s.d. of three independent experiments, performed in triplicates. Cells were grown as adherent monolayers. n.d. = not determined.