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Table 3 The top up- and down-regulated genes involved in the significant enrichment pathway

From: Gene expression profile analyze the molecular mechanism of CXCR7 regulating papillary thyroid carcinoma growth and metastasis

Genes

Description

log2(Ratio) O/N

p value (Differentially expressed)

KEGG_ECM_RECEPTOR_INTERACTION

FN1

Fibronectin 1

5.5287

0

COL1A1

Collagen, type I, alpha 1

4.3820

0

COL5A1

Collagen, type V, alpha 1

3.2131

9.73E-21

COL4A1

Collagen, type IV, alpha 1

2.0595

5.54465E-06

VWF

von Willebrand factor

1.9795

7.64103E-09

LAMA1

Laminin, alpha 1

1.5764

1.77592E-09

TNC

Tenascin C (hexabrachion)

1.0455

6.29032E-07

ITGA6

Integrin, alpha 6

−1.1582

0.001988898

LAMA3

Laminin, alpha 3

−1.5196

1.55E-14

ITGA7

Integrin, alpha 7

−1.9969

8.53527E-12

KEGG_FOCAL_ADHESION

FN1

Fibronectin 1

5.5287

0

COL1A1

Collagen, type I, alpha 1

4.3819

0

PDGFRB

Platelet-derived growth factor receptor, beta polypeptide

3.7321

1.37E-43

COL5A1

Collagen, type V, alpha 1

3.2131

9.73E-21

SHC2

SHC (Src homology 2 domain containing) transforming protein 2

2.1832

2.58E-15

COL4A1

Collagen, type IV, alpha 1

2.0595

5.545E-06

VWF

von Willebrand factor

1.9795

7.641E-09

LAMA3

Laminin, alpha 3

−1.5196

1.55E-14

TNFRSF25

Tumor necrosis factor receptor superfamily, member 25

−1.7049

6.82E-27

ITGA7

Integrin, alpha 7

−1.9969

8.535E-12

KEGG_MAPK_SIGNALING_PATHWAY

PDGFRB

Platelet-derived growth factor receptor, beta

3.7321

1.37E-43

CD14

CD14 molecule

2.7194

7.86E-15

DUSP1

Dual specificity phosphatase 1

2.0457

2.363E-06

PLA2G2A

Phospholipase A2, group IIA (platelets, synovial fluid)

1.9008

5.062E-07

NTRK2

Neurotrophic tyrosine kinase, receptor, type 2

1.8524

1.126E-11

CACNA1I

Calcium channel, voltage-dependent, alpha 1I subunit

1.4363

1.27E-18

ATF4

Activating transcription factor 4 (tax-responsive enhancer element B67)

−1.6707

7.347E-05

PRKACB

Protein kinase, cAMP-dependent, catalytic, beta

−1.7679

2.745E-12

MAP3K4

Mitogen-activated protein kinase kinase kinase 4

−2.1767

0.0014161

NFKB2

Nuclear factor of kappa light polypeptide gene enhancer

−2.2731

1.01E-15

KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION

PDGFRB

Platelet-derived growth factor receptor, beta polypeptide

3.7321

1.37E-43

LTB

Lymphotoxin beta (TNF superfamily, member 3)

2.9402

1.67E-33

CXCL12

Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)

2.7037

5.32E-22

CCL5

Chemokine (C-C motif) ligand 5

2.5225

5.837E-10

CCL21

Chemokine (C-C motif) ligand 21

1.8655

4.374E-07

TNFRSF4

Tumor necrosis factor receptor superfamily, member 4

1.7509

1.69E-15

CXCL2

Chemokine (C-X-C motif) ligand 2

1.4616

3.49E-14

IL23A

Interleukin 23, alpha subunit p19

−1.2503

8.442E-08

ACVR2A

Activin A receptor, type IIA

−1.6469

1.865E-07

TNFRSF25

Tumor necrosis factor receptor superfamily, member 25

−1.7049

6.82E-27

  1. Note: log 2(Ratio) O/N is the logarithm of fluorescence intensity ratio of O and N, where O the experimental group (K1 cell transfected with CXCR7), and N is the control group (K1 cell). |log2 ratios| ≥ 1 and P < 0.05 means the differentially expression genes; P value indicates the significance of log2 (Ratio) O/N.