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Figure 1 | Journal of Experimental & Clinical Cancer Research

Figure 1

From: DEC2 expression is positively correlated with HIF-1 activation and the invasiveness of human osteosarcomas

Figure 1

HIF-1α levels in human osteosarcoma are correlated to disease-free survival (DFS). A. Paraffin-embedded osteosarcoma tissues were retrieved and deparaffinized and used in immunohistochemical studies. The pathological diagnosis was re-confirmed. Representative micrographs for immunohistochemical staining of HIF-1α (right) and DEC2 (left) were shown. Magnification: 40 ×. B. Kaplan-Meier plot showing DFS in osteosarcoma patients, stratified according to positive or negative expression levels of HIF-1α. Primary osteosarcoma tissues with scale 2 and 3 of HIF-1α expression were classified as HIF-1α positive, scale 0 and 1, negative. C. A diagram showing the distribution of DEC2 positive and HIF-1α positive cases in osteosarcoma samples, showing a striking positive correlation.

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