Figure 6From: DEC2 expression is positively correlated with HIF-1 activation and the invasiveness of human osteosarcomas Proposed model showing the intriguing functional DEC2-HIF-1 association in the progression of osteosarcoma. In osteosarcomas, a combination of hypoxia and oncogenic signaling may increase the levels of HIF-1α, which upregulates DEC2 expression. DEC2 in turn facilitates the stabilization of HIF-1α, sensitizing osteosarcoma cells to hypoxic or oncogenic signaling and rapidly activating HIF-1 function.Back to article page