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Figure 6 | Journal of Experimental & Clinical Cancer Research

Figure 6

From: DEC2 expression is positively correlated with HIF-1 activation and the invasiveness of human osteosarcomas

Figure 6

Proposed model showing the intriguing functional DEC2-HIF-1 association in the progression of osteosarcoma. In osteosarcomas, a combination of hypoxia and oncogenic signaling may increase the levels of HIF-1α, which upregulates DEC2 expression. DEC2 in turn facilitates the stabilization of HIF-1α, sensitizing osteosarcoma cells to hypoxic or oncogenic signaling and rapidly activating HIF-1 function.

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