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Figure 5 | Journal of Experimental & Clinical Cancer Research

Figure 5

From: MiR-223 promotes the cisplatin resistance of human gastric cancer cells via regulating cell cycle by targeting FBXW7

Figure 5

Over-expression of FBXW7 could mimic the effect miR-223 inhibitor on the sensitivity of 7901/DDP cells. (A) qRT-PCR and western blot detection of FBXW7 mRNA and protein expression in 7901/DDP/NC or 7901/DDP/FBXW7 cells; (B) MTT analysis of the IC50 values of DDP in 7901/DDP/NC or 7901/DDP/FBXW7 cells; (C) Flow cytometric analysis of cell cycle in 7901/DDP/NC or 7901/DDP/FBXW7 cells combined with DDP (0 and 2.0 ug/ml); (D) Flow cytometric analysis of apoptosis in 7901/DDP/NC or 7901/DDP/FBXW7 cells combined with DDP (0 and 2.0 ug/ml). Results represent the average of three independent experiments (mean ± S.D.). *p < 0.05.

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