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Table 1 Anti-proliferative activity (IC 50 values) of 2-DG alone and in combination with platinum analogs and/or SB202190

From: The anti-tumor efficacy of 2-deoxyglucose and D-allose are enhanced with p38 inhibition in pancreatic and ovarian cell lines

Cell line 2-DG (mM) Platinum (μM) 2-DG + Platinum 2-DG + 20uM SB202190 (mM) Platinum + 20uM SB202190 (uM) 2-DG + 20 μM SB202190 + Platinum
2-DG (mM) Platinum (μM) CI at IC50 2-DG (mM) Platinum (μM)
MIA PaCa-2 1.45 3.37 0.95 0.48 0.796 0.48 19.72 0.24 0.12
BxPC-3 10.80 28.13 8.12 4.06 0.896 0.60 32.50 1.23 0.61
ASPC-1 11.47 >50 10.55 5.25 0.954 4.90 >50 5.77 2.88
OVCAR-3 3.39 6.93 3.39 1.69 1.243 3.9 26.45 4.1 2.05
HEY 10.17 32.90 9.88 4.94 1.122 2.63 50> 2.44 1.22
SK-OV-3 13.34 11.53 6.46 3.23 0.764 1.42 21.05 2.01 1.01
  1. IC50 values represent the level of drug that inhibited cell growth by 50% following 48 hours of treatment. Combination index (CI) values are defined as: <0.1 = very strong synergy, 0.1-0.3 = strong synergism, 0.3-0.7 = synergism, 0.7 – 0.85 = moderate synergism, 0.85-0.9 = slight synergism, 0.9-1.1 = nearly additive, 1.1-1.45 slight to moderate antagonism.