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Table 2 Anti-proliferative activity (IC 50 values) of D-allose alone and in combination with platinum analogs and/or SB202190

From: The anti-tumor efficacy of 2-deoxyglucose and D-allose are enhanced with p38 inhibition in pancreatic and ovarian cell lines

    D-allose + Platinum D-allose + 20 μM SB202190 (mM) D-allose + 20 μM SB202190 + Platinum
Cell line D-allose (mM) Platinum (μM) D-allose (mM) Platinum (μM) CI at IC50 D-allose (mM) Platinum (μM)
MIA PaCa-2 53.25 3.37 4.16 0.95 0.696 3.18 1.98 0.99
BxPC-3 >100 28.13 43.3 21.65 0.787 4.09 8.75 4.38
ASPC-1 >100 >50 >100 >50 n/c 74.11 >100 >50
OVCAR-3 >100 6.93 15.84 7.92 1.171 >100 51.7 25.85
HEY >100 32.90 52.68 26.34 1.002 94.17 53.01 26.5
SK-OV-3 >100 11.53 18.55 9.27 0.857 10.82 9.74 4.87
  1. IC50 values represent the level of drug that inhibited cell growth by 50% following 48 hours of treatment. Combination index (CI) values are defined as: <0.1 = very strong synergy, 0.1-0.3 = strong synergism, 0.3-0.7 = synergism, 0.7 – 0.85 = moderate synergism, 0.85-0.9 = slight synergism, 0.9-1.1 = nearly additive, 1.1-1.45 slight to moderate antagonism.